ClinicalAnalysisof61casesofdrug-inducedliverNetworkofpapers:[Abstract]ObjectiveToinvestigatetheclinicalfeaturesofdruginducedliverdiseaseandthecausativedrugs.MethodsAretrospectiveanalysisof61casesofdruginducedliverdiseaseinhospitalizedpatientsmedicationhistory,underlyingdiseases,clinicalmanifestations,laboratorytests,treatment,transfernormalizedanalyzetheresultsofmultipledrugscancauseliverdamageinChinesemedicineforupto22cases,accountingfor36.06percent,followedbyantibiotics(includinganti-TBdrugs,16cases,accountingfor26.23%,theclinicalclassificationoflivercellinjurytypecommon,48cases,accountingfor78.69%,eightcasesofcholestasis,accountingfor13.11%,mixedtypein5cases,accountingfor8.20%,themainclinicalmanifestationsarejaundice,fatigue,anorexia,impairedliverfunctionofALT,AST,GGTandALPincreasedmainly.clinicalimprovementratewas72.13%,21.31%curerateandcasefatalityrateof3.27%.Conclusion(1)multi-drugcausecancausedrug-induced1liverinChinesemedicineforthemostcommon,(2)druginducedliverdiseasetolivercelldamage.[KeyWords]theclinicalfeaturesofdruginducedliverdiseasedrugDruginducedliverdisease(drug-inducedliverinjury,DILIinliverdamagecausedbydrugsorcertainmetabolitestothevariouscellsofthelivercanbeaffectedbydrugdamage,isoneofthecommonliverdisease,theincidencerateafterviralhepatitis,fattyliverdisease(alcoholicandnonalcoholic.Withthecontinuousadventofnewdrugs,theoccurrenceofdruginducedliverdiseaseisalsoacorrespondingincreaseinknowntohavemorethan1000kindsofdrugscanleadtoliverdamage,becauseofitsclinicalmanifestations,laboratoryroomtochecknon-specific,pronetomissedormisdiagnosed,nowusingtheretrospectivemethodforclinicalanalysisof61casesofdruginducedliverdiseaseinhospitalizedpatients.MaterialsandMethods(1)GeneralInformationInpatientmedicalhomebetweenJanuary2006toMarch2009bytheFirstAffiliatedHospitalofGuangxiMedical2RecordManagementsoftwarequerycontainsa“druginducedliverdiseasediagnosedcases,142werebasedonthe1997Maria”drug-inducedliverdamagediagnosticscore“score(outof20points,thetotalscore>=14points,atotalof61casesincludedinthisstudy.(2)theclinicalclassificationReferencetotheMedicalScienceInternationalOrganizingCommittee(CIOMSrecommendeddruginducedliverdiseaseclassificationcriteriawereclassified,anddividedintothreetypes①livercellinjurytype:alanineaminotransferase(ALT)greaterthan2timesnormal,orALT/ALP(alkalinephosphatase>=5,②cholestasistype:ALPgreaterthantwotimesnormalandtheALT/ALP≤2,(3)mixedtype:ALTgreaterthan2timesnormal,ALP>2timesnormalandtheALT/ALPfor2to5.(3)ClinicalcriteriaforjudgingHospitalizationwithin30daysofALT,AST,TBILandrecoverytolessthan2timestheupperlimitofnormal,(2)improved:theseindicatorshasbeenrestored,butstillmorethan2timestheupperlimitofnormal①Thecure:donotimprove,3(3):theseindicatorsimprovedsignificantlyoraggravated④Death:diedduringhospitalization.4MethodsRecordeachpatient’sgender,age,medicationhistory,medicalhistory,clinicalsymptoms,signs,biochemicalindicators(ALTandAST,ALP,andGGT,A/G,TBIL,DBILbloodaswellastreatmentandoutcomeforallthepatient’smedicalrecordswereretrospectivelyanalyzed.countdatarate,orconstitutemorethan,andweresaid.(5)statisticalmethodsSPSS13.0statisticalsoftpackageforstatisticalanalysisofthedata,χ2test,p<0.05statisticallysignificant.Result(1)IngeneralClinicaldiagnosisofdruginducedliverdisease61cases,33casesweremaleand28females,average(42.87+-10.22)yea...