神经节苷脂和纳洛酮联合治疗新生儿缺氧缺血性脑病的效果及对NBNA【摘要】目的探?单唾液酸四己糖神经节苷脂钠注射液（简称神经节苷脂）和纳洛酮联合治疗新生儿缺氧缺血性脑病（HIE）的疗效及对新生儿行为神经测定（NBNA）评分的影响。方法88例新生儿缺氧缺血性脑病患儿随机分为研究组与对照组，每组44例。在基础对症支持治疗基础上，对照组给予纳洛酮治疗，研究组给予纳洛酮联合神经节苷脂治疗，10d为1个疗程，共治疗3个疗程，评价两组疗效并在每个疗程结束后记录NBNA评分。结果经过3个疗程的治疗，研究组临床治疗总有效率为88.64%，明显高于对照组的70.45%，差异具有统计学意义（P<0.05）。治疗1个疗程结束，两组NBNA评分比较差异无统计学意义（P>0.05）；而在第2个疗程结束及第3个疗程结束时，研究组NBNA评分分别为（34.44±2.36）分、（37.42±2.39）分，显著高于对照组的（33.21±2.78）分、（35.01±2.46）分，差异具有统计学意义（P<0.05）。结论神经节苷脂和纳洛酮联合治疗新生儿缺氧缺血性脑病能够显著改善患儿的症状及体征，有助于NBNA评分改善，提高治疗疗效，适合推广使用。【关键词】单唾液酸四己糖神经节苷脂钠注射液；纳洛酮；新生儿缺氧缺血性脑病；新生儿行为神经测定评分DOI：10.14163/jki.11-5547/r.2017.16.061Effectbygangliosideandnaloxoneincombinedtreatmentofneonatalhypoxic-ischemicencephalopathyandtheirinfluenceonNBNAscoreMENGNa-na，LANHai-yan.ZhaoqingMedicalCollege，Zhaoqing526000，China【Abstract】ObjectiveToinvestigatecurativeeffectbymonosialoteterahexosylgangliosidesodiuminjection（gangliosideforshort）andnaloxoneincombinedtreatmentofneonatalhypoxic-ischemicencephalopathy（HIE）andtheirinfluenceonneonatalbehavioralneurologicalassessment（NBNA）score.MethodsAtotalof88childrenpatientswithneonatalhypoxic-ischemicencephalopathywererandomlydividedintoresearchgroupandcontrolgroup，with44casesineachgroup.Onthebasisofconventionalsymptomaticandsupportivetreatment，thecontrolgroupreceivednaloxonefortreatment，andtheresearchgroupreceivednaloxonecombinedwithgangliosidefortreatment.1treatmentcourselastedfor10d，andbothgroupsreceived3treatmentcourses.Evaluationwasmadeoncurativeeffectsinthetwogroups，andNBNAscoresaftereachtreatmentcoursewererecorded.ResultsAfter3treatmentcourses，theresearchgrouphadobviouslyhighertotaleffectiverateinclinicaltreatmentas88.64%than70.45%inthecontrolgroup，andtheirdifferencehadstatisticalsignificance（P<0.05）.Attheendofthefirsttreatmentcourse，therewasnostatisticallysignificantdifferenceofNBNAscorebetweenthetwogroups（P>0.05）.Attheendofthesecondandthirdtreatmentcourse，theresearchgrouphadobviouslyhigherNBNAscoresas（34.44±2.36）and（37.42±2.39）pointsthan（33.21±2.78）and（35.01±2.46）pointsinthecontrolgroup，andtheirdifferencehadstatisticalsignificance（P<0.05）.ConclusionCombinationofgangliosideandnaloxonecanremarkablyimprovesymptomsandvitalsignsinchildrenpatientswithneonatalhypoxic-ischemicencephalopathy.ThismethodishelpfultoimproveNBNAscoreandenhancecurativeeffectintreatment，anditissuitableforpromotionandapplication.【Keywords】Monosialoteterahexosylgangliosidesodiuminjection；Naloxone；Neonatalhypoxic-ischemicencephalopathy；Neonatalbehavioralneurologicalassessment新生儿缺氧缺血性脑病指的是围生期发生缺氧或者脑组织血流量的下降，胎儿或新生儿发生脑损伤，患儿中枢神经系统发生慢性损伤以及永久的神经功能损伤，病情严重患儿甚至会危及生命[1]。目前该病的死亡率较高，给予及时有效的治疗能够显著缓解病情，减少对患儿神经功能造成的损害，临床治疗方面主要以促进患儿神经功能恢复为主，研究显示，使用单一药物并没有较为理想的效果，目前临床...