人参“异病同治”糖尿病和勃起功能障碍的网络药理学机制探究赵琦王宁闫菲代恒恒王浩浩邝浩冯隽龙---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除------本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---摘要目的：運用网络药理学方法预测人参治疗糖尿病和勃起功能障碍的活性成分、作用靶标与关键通路，以探究人参“异病同治”的作用机制。方法：通过检索中医药证候关联数据库（SymMap）、中药系统药理学数据库和分析平台（TCMSP）和中药分子机制的生物信息学分析工具（BATMAN）获取人参所含成分及靶标，结合OMIM、GeneCards疾病数据库分别获取糖尿病和勃起功能障碍2种疾病的共同靶标，将二者取交集得到药物-疾病蛋白质靶标并导入STRING平台进行蛋白质交互网络分析，并通过Cytoscape软件构建网络模块及基因本体（GO）富集分析和京都基因和基因组百科全书（KEGG）通路功能注释。结果：人参治疗糖尿病和勃起功能障碍共病机制与药物应答、缺氧应答、腺苷酸环化酶激活肾上腺素能受体的信号转导途径、血管收缩调节、对尼古丁的反应等生物学功能相关联，主要通过调节cGMP-PKG、核因子κB、HIF-1、TNF等信号通路来实现异病同治的作用。结论：人参治疗糖尿病和勃起功能障碍的共病作用---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---机制主要是通过参与血管生成、促进增殖细胞的迁移和趋化、降低血管内炎症等多途径综合干预，从而发挥单味中药“异病同治”的药效作用。关键词网络药理学;人参;糖尿病;勃起功能障碍;异病同治;蛋白质互作;信号通路;血管生成ResearchontheMechanismofNetworkPharmacologyofRadixGinsengfor“DifferentDiseaseswiththeSameTreatment”inDiabetesMellitusandErectileDysfunctionZHAOQi1，WANGNing2，YANFei1，DAIHengheng1，WANGHaohao1，KUANGHao1，FENGJunlong1，DENGSheng1，WANGShizhen1，XUHongsheng1，LIHaisong3（1Bei激ngUniversityofTraditionalChineseMedicine，Bei激ng100029，China;2ZhongweiHospitalofTraditionalChineseMedicine，NingxiaHuiAutonomousRegion，Zhongwei755000，China;3DongzhimenHospital，Bei激ngUniversityofTraditionalChineseMedicine，Bei激ng100700，China）AbstractObjective：Tousenetworkpharmacologymethodstopredicttheactiveingredients，targetsandkeypathwaysofRadixGinsenginthetreatmentofdiabetesmellitusanderectiledysfunction，soastoexplorethecommonmechanismofthetraditionalChinesemedicine“treatingdifferentdiseaseswiththesametreatment”.Methods：ThroughsearchingSymMap，TCMSPandBATMANdatabase，weobtainedthecomponentsandtargetsofRadixGinsengbinedwithOMIM，GeneCardsdiseasedatabase，weobtainedthecommontargetsofdiabetesmellitusanderectiledysfunctionrespectively.Wetooktheintersectionofthe2toobtainthedrug----本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---diseaseproteintargetandimporteditintotheSTRINGplatformforproteininteractionnetworkanalysis，andusedCytoscapesoftwaretoconstructanetworkmoduleandGOenrichmentanalysisandKEGGpathwayfunctionannotation.Results：ThemechanismandbiologicalfunctionsofRadixGinsenginthetreatmentofdiabetesmellitusanderectiledysfunctionwererelatedtodrugresponse，hypoxiaresponse，adenylatecyclaseactivationofadrenergicreceptorsignaltransductionpathway，vasoconstrictionregulationandresponsetonicotine.Correlation，mainlythroughtheregulationofcGMP-PKG，NF-κB，HIF-1，TNFandothersignalpathwaystoachievethesametreatmentofdifferentdiseases.Conclusion：ThemechanismofRadixGinsenginthetreatmentofdiabetesmellitusanderectiledysfunctionismainlythroughtheparticipationinangiogenesis，promotingthemigrationandchemotaxisofproliferatingcells，reducingintravascularinflammationandothercompreh...