盐酸西替利嗪递减疗法联合复方甘草酸苷对慢性荨麻疹患者血清IgE[摘要]目的探?盐酸西替利嗪递减疗法联合复方甘草酸苷对慢性荨麻疹患者血清IgE及IL-6水平的影响。方法选取2015年9月～2016年12月佛山市南海区第七人民医院收治的100例慢性荨麻疹患者为研究对象，采用随机数字表法分为联合组和单项组各50例，选取同期30例健康体检者作为对照组，联合组患者采用盐酸西替利嗪递减疗法联合复方甘草酸苷治疗，单项组患者单纯采用盐酸西替利嗪递减疗法治疗，两组患者均连续治疗6周，对比两组患者的疗效，并对比三组受检者治疗前后血清IgE及IL-6水平的变化情况。结果联合组患者总有效率为98.0%，显著高于单项组的86.0%，差异有统计学意义（P<0.05）。治疗前，联合组及单项组患者的IgE水平显著高于对照组（P<0.05）；治疗后，两组患者的IgE水平均显著降低，但仍显著高于对照组，联合组患者的IgE水平改善程度显著优于单项组（P<0.05）；治疗前、治疗后联合组及单项组患者的IL-6水平与对照组比较，差异无统计学意义（P>0.05）。结论盐酸西替利嗪递减疗法联合复方甘草酸苷治疗慢性荨麻疹能够显著提升效果，改善患者血清IgE水平，但对患者血清IL-6的水平并无明显影响，提示IL-6水平可能与慢性荨麻疹无明显相关性。[关键词]慢性荨麻疹；盐酸西替利嗪；复方甘草酸苷；IgE；IL-6[]R758.24[文献标识码]A[]1674-4721（2017）03（c）-0027-03[Abstract]ObjectiveToinvestigatetheeffectofCetirizineHydrochloridereductiontherapycombinedwithCompoundGlycyrrhizinonserumIgEandIL-6levelsinpatientswithchronicurticaria.MethodsAtotalof100patientswithchronicurticariaadmittedtoNanhaiDistricttheSeventhPeople′sHospitalofFoshanCityfromSeptember2015toDecember2016wereselectedasstudyobjectanddividedintocombinedgroupandsinglegroupaccordingtotherandomnumbertablemethod，50casesineachgroup，30healthysubjectswereselectedascontrolgroup.PatientsinthecombinedgroupweretreatedwithCetirizineHydrochloridereductiontherapycombinedwithCompoundGlycyrrhizin，andpatientsinthesinglegroupweretreatedwithCetirizineHydrochloridereductiontherapy，patientsoftwogroupsweretreatedcontinuouslyfor6weeks.Curativeeffectbetweenthecombinedgroupandthesinglegroup，changesofserumIgEandIL-6levelsbeforeandaftertreatmentamongthreegroupswerecompared.ResultsThetotaleffectiverateofthecombinedgroupwas98.0%，whichwassignificantlyhigherthanthatofthesinglegroup（86.0%），andthedifferencewasstatisticallysignificant（P<0.05）.ThelevelofIgEbeforetreatmentinthecombinedgroupandthesinglegroupwassignificantlyhigherthanthatinthecontrolgroup（P<0.05）；aftertreatment，thelevelsofIgEinthecombinedgroupandthesinglegroupwassignificantlylower，butwhichwasstillsignificantlyhigherthanthatinthecontrolgroup，thelevelofIgEinthecombinedgroupwassignificantlybetterthanthatofthesinglegroup（P<0.05）；comparedwiththecontrolgroup，thelevelsofIL-6beforeandaftertreatmenthadnosignificantdifferentinthecombinedgroupandthesinglegroup（P>0.05）.ConclusionCetirizineHydrochloridereductiontherapycombinedwithCompoundGlycyrrhizininthetreatmentofchronicurticariacansignificantlyimprovethecurativeeffectandtheserumIgElevel，butthereisnosignificanteffectonserumIL-6level，itissuggestedthatthelevelofIL-6maynotbeassociatedwithchronicurticaria.[Keywords]Chronicurticaria；CetirizineHydrochloride；CompoundGlycyrrhizin；IgE；IL-6慢性荨麻疹是一种常见的变应性皮肤病，主要是皮肤和黏膜小血管渗透性增强而形成的一种局部水肿反应，该反应持续发生，持续时间>6周则被称为慢性荨麻疹[1]。该病的发病机制较为复杂，可能与遗传、免疫、环境等因素有关，发病年龄广泛，但成年人较多，病情预后差，易反复发作，严重影响患者的生活质量[2]。传统治...