elF4E表达在大肠肿瘤发生发展中的作用及其潜在的诊断价黄金凤1雍伟伟2姚运红2吴孟宴2康海仙2尹金宝2敖秋月2别延红2胡新荣2（通讯作者）（1佛山市顺德区屮医院病理科广东顺德528333）（2广东医学院肿瘤研宂所、病理教研室广东东莞523808）【摘要】目的：探讨elF4E蛋白表达在大肠癌发生发展屮的作用和诊断意义。方法：用免疫组化方法检测145例大肠石蜡标本的elF4E表达。病例包括大肠炎25例、腺瘤40例、腺癌40例、转移性腺癌40例。结果：依人肠炎、腺瘤、腺癌、转移性腺癌的次序,elF4E阳性表达率分别为12.0%、80.0%、85.0%、100%,其屮大肠炎组分别与其他三组比较，P<0.01；腺瘤组与腺癌组比较，P>0.05;腺瘤组和腺癌组分别与转移性腺癌组比较，P<0.05o依I、II、III、IV临床分期次序,elF4E阳性表达率分别为62.5%、82.8%、96.6%、100%,P<0.01。elF4E阳性表达与性别、年龄、发生部位、浸润深度、分化程度等无关。elF4E阳性表达从大肠炎屮诊断腺瘤的敏感性为85.0%，特异性为88.0%;从腺瘤屮诊断腺癌的敏感性为92.5%,特异性为17.7%。结论：elF4E在大肠粘膜演变成腺瘤和腺癌、从未转移性腺癌演变成转移性腺癌、从早期癌到晚期癌屮表达显著升高，提示elF4E可以促进大肠肿瘤的发生发展，具有潜在的预后和诊断价值。【关键词】大肠肿瘤elF4E转移【屮图分类号】R735.3+4【文献标识码】A【文章编号】2095-1752（2013）18-0393-03TheroleanddiagnosisvalueoftheexpressionofelF4EintheoccurrenceanddevelopmentofcolorectaltumorsHuangJinfenglYonWeiwei2YaoYunhong2WuMengyan2KangHaixian2YinJinbao2AoQiuyue2BieYanhong2HuXinrong2（Correspondentauthor）---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---(1Departmentofpathology,ShundetraditionalChinesemedicalhospital,Shunde,528333；2Departmentofpathology,cancerinstitute,GuangdongMedicalCollege,Dongguan523808)【Abstract】Objective:ToexploretheroleofelF4EinoccurrenceanddevelopmentofcolorectaltumorsandthediagnosisvalueoftheelF4Eexpression.Methods:ImmunohistochemistrywasusedtodetecttheelF4Eexpressionin145casesofcolorectaltissues.Thecasesincluded25colitis,40adenomas,40adenocarcinomasand40metastaticadeno-carcinomas.Results:Intheorderofcolitis,adenoma,adenocarcinomaandmetastaticadenocarcinoma,theelF4Eexpressionrateswere12.0%,80.0%,85.0%and100%，respectively,P<0.01betweencolitisandthethreetumorgroups,P>0.05betweenadenomaandadenocarcinoma,andP<0.05betweenadenomaandadenocarcinomaandmetastaticadenocarcinoma.IntheorderoftheclinicalphaseI,II,IIIandIVofthemalignancies,theexpressionratesofelF4Ewere62.5%、82.8%、96.6%、100%，respectively,P<0.01.TherewasnosignificantdifferencebetweentheexpressionofelF4Eandtheageandgenderofthepatients,andthelocation,invasivedeepnessanddifferentiationofthemalignancies.FortheelF4Eexpressiontodiagnoseadenomafromcolitis,thesensitivitywas85.0%andthespecificitywas88.0%.FortheelF4Eexpressiontodiagnoseadenocarcinomafromadenoma,thesensitivitywas92.5%andthespecificitywas17.7%.Conclusion:TheexpressionofelF4Esignificantlyincreasesduringtheevolutionfromcolitistoadenomaandthenadenocarcinoma,fromadenocarcinomatometastaticadenocarcinoma,andfromtheearlyphasetothelatephaseofcolorectalcarcinoma.TheresultindicatedthatelF4Emayinitiateandpromotecololectaladenocarcinoma,andtheexpressionofelF4Emighthaveapotentialvaluetodiagnoseandprognosescolorectaltumors.【Keywords】ColorectaltumorelF4Emetastaisi大肠癌（结直肠癌）是我国常见的恶性肿瘤，其发病率及病死率冇逐年增---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---高的趋势。大肠癌的发生与遗传因素和环境因素相关，与腺瘤向腺癌的转化及多种癌基因和抑癌基因的综合失调有关［1-4］...