早发型重度子痫前期的临床特点及围生结局[摘要]目的探讨早发型重度子痫前期的临床特点及期待治疗围生结局的影响。方法回顾性分析我院2002年10月~2010年10月收治的早发型重度子痫前期170例，根据发病孕周不同分成三组：A组（28周≤孕周＜30周）25例，B组（30周≤孕周＜32周）63例，C组（32周≤孕周＜34周）82例，比较三组间期待治疗及围生儿结局。结果①不同发病孕周妊娠并发症（肝肾功能损害、胎盘早剥、HELLP综合征、心衰肺水肿、视网膜病变）比较差异无统计学意义（P＞0.05）；②不同发病孕周期待治疗时间比较差异有统计学意义（P＜0.05），A组＞B组＞C组，即随着发病孕周延长，期待治疗时间缩短。结论不同早发型重度子痫的发病孕周对妊娠并发症无明显影响，发病孕周越大，其期待治疗时间越短，孕32周之前发病的重度子痫前期围生儿死亡率及新生儿窒息率明显高于32周后发病者。[关键词]早发型重度子痫前期；并发症；围生结局[]R714.24+5[文献标识码]A[]1673-7210（2012）02（a）-0034-02PerinataloutcomesandclinicalfeaturesinearlyonsetseverepreeclampsiaLINGShaoyunCHENGYanjunWUXueqinDepartmentofObstetricsandGynecology,LonggangCentralHospitalofShenzhenCity,GuangdongProvince,Shenzhen518116,China[Abstract]ObjectiveToexploretheimpactofexpectanttreatmentontheperinatalinfantileoutcomeandclinicalfeaturesinearlyonsetseverepreeclampsia(ES2PE).Methods170caseswithearlyonsetseverepreeclampsiaadmittedtothehospitalfromOctober2002toOctober2010wereanalyzedretrospectively,thentheyweredividedintothreegroupsaccordingtoonsetgestationalweeks:groupA(28weeks≤gestationalweeks＜30weeks)25cases,groupB(30weeks≤gestationalweeks＜32weeks)63cases,groupC(32weeks≤gestationalweeks＜34weeks)82cases,thecurativeeffectsofexpectanttreatmentandperinataloutcomesinthethreegroupswerecompared.Results①Therewasnosignificantdifferenceinincidenceofmaternalcomplications(liverandkidneyfunctiondamage,placentalabruption,HELLPsyndrome,heartfailurewithpulmonaryedema,retinallesions)amongthethreegroups(P>0.05);②therewassignificantdifferenceinexpectanttreatmenttimeamongthethreegroups(P＜0.05),groupA>groupB>groupC,theexpectanttreatmentwereshorterwiththeonsetofgestationalweekincreased.ConclusionDifferentgestationalageofearlyonsetseverepreeclampsiahasnosignificanteffectoncomplicationsofpregnancy,thegreaterthegestationalageis,theshortertheexpectedtreatmenttimebecome,theperinatalmortalityandneonatalasphyxiarateofseverepreeclampsiaoccurredbefore32weeksishigherthanthatoccurredafter32weeks.---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---[Keywords]Earlyonsetseverepreeclampsia;Complication;Perinataloutcome重度子痫前期是妊娠期特有的、严重的并发症，是导致孕产妇及围生儿死亡的重要原因之一。早发型重度子痫前期（earlyonsetseverepreeclampsia，ES2PE）因发病早、程度严重，有较高的围生儿死亡率。但迄今为止，早发型前期重度尚无统一界定，有学者将发病于32周前或34周前的重度子痫前期称为早发型重度子痫前期[1]，在此后发病称为晚发型重度子痫前期[2]。本文通过对我院收治的170例孕周≤34周的重度子痫前期进行回顾性分析，探讨早发型重度子痫前期的临床特点及围生儿结局，以期提高围生儿生存率，减少围生期母婴不良结局。现报道如下：1资料与方法1.1一般资料2002年10月~2010年10月在我院住院的孕产妇共24566例，围生儿总数24517例，新生儿死亡113例，新生儿轻度窒息383例，重度窒息117例。孕产妇中确诊早期重度子痫前期204例（34例因子痫、胎盘早剥、胎死宫内等并发症或治疗后病情不稳定判为不宜期待治疗，入院后2~48h内终止妊娠），其余170例根据其入院孕周不同分为三组，即A组（28周≤孕周＜30周）25例，B组（30周≤孕周＜32周）63例，C组（32周≤...