滋阴益气活血解毒法治疗2型糖尿病合并脂肪肝临床观察摘要：日的：探讨滋阴益气活血解离法对2型糖尿病(T2DM)合并脂肪肝(NAFLD)患者空腹血糖、血脂、肝功能、肝脏影像学的影响。方法：将符合入选标准的60例患者随机分为对照组和治疗组，各为30例，均进行糖尿病常规治疗■饮食体质址控制、加强运动并使用口服降糖约物调节血糖。对照组服用肝旨清胶囊，治疗组服用肝旨清胶囊加用滋阴益气活血解毒组方中纱治疗。两组疗程均为5个月，评定治疗后的临床疗效。结果：两组病例治疗前各项检查指标比较无统计学意义(P>0.05)；经治疗后，对照组和治疗组空腹血糖、餐后2h血糖、血脂、肝功能和脂肪肝等级与治疗前比较，差异具有统计学意义(P<0.05或0.01),除空腹血糖外，治疗组各项检查指标优于对照组，差异具有统计学意义(P<0.05或0.01)；治疗组总体疗效优于对照组,,差异具有统计学意义(Pv().()1)。结论：滋阴益气活血解毒法对2型糖尿病合并脂肪肝患者空腹血糖、血脂、肝功能均有改善作用。关键词：2型糖尿病合并脂肪肝；肝功能；滋阴益气活血解毒法StudyonclinicalefficacyofthemothodofZiyinYiqiHuoxueJieduimposedonthetype2mellituswithnon-alcoholicfattyliverZhangqim,ChengXihua2,YuRong2(1.GraduateInstituteofEducation2010GraduateofHunanUniversityofTraditionalChineseMedicine,ChangSha410208;2.HunanUniversityofTraditionalChineseMedicine,SchoolofMedicine,ChangSha410208)Abstract:Objective:ToobservetheclinicalefficacyofthemothodofZiyinYiqiHuoxueJieduimposedonthetype2mellituswithnon-alcoholicfattyliver.Method:Teselected60patientswithtype2diabetesmellituswithnon-alcoholicfattyliverwhichwerediagnosedwithdeficiencyofbothyinandqi,turbidphlegmbloodstasisbyTCM・Thesepatientsweredividedintocontrolandtherapygroupsrandomly.Theyallperlormedbasictreatment,likeoralantidiabeticdrugand,LiverpurposeQingCapsule,dietcontrolaswellasmoreexercisetoregulatethebloodglucoselevel,whilethepatientsoftherapygroup,inadditiontotheabovetreatment,weregiventheChinesemedicineofZiyinYiqiHuoxueJiedu•Thetreatmentperiodwas5months.Liverultrasoundexaminationandbiochemicaltests(thefastingbloodglucose,2hourpostprandialbloodglucose.includingbloodlipid,liverfunction)aswellasthetotaleffectwereearnedoutforthose60patientsbeforeandafterthetreatmeResult:Therewasnosignificantdifferencebetweenthefattyliverdegreeandbiochemicaltestsoftwogroupsbeforetreatment(P>().05)・After5months,thebloodglucose,2hourpostprandialfastingbloodglucose,thebloodlipid,liverfunctionandthefatlyliverdegreeofthetwogroupswereallimprovedtodifferentdegrees(P<().05,0.0I),“ndthoseofthetherapygroupexceptthefastingbloodglucoseimprovedmoresignificantly(P<0.05,0.01).Therewassignificantdifferencebetweentthetotaleffectoftwogroupsaftertreatnient(P<0.01).Conclusion:ThemothodofZiyinYiqiHuoxueJieduhada基金项目：国家自然科学基金(No.81102593,81273753)，中国博士后科学基金(No.20110491258)，教育部博士学科点科研基金(No.20104323110002,20094323120001),湖南省教育厅优秀青年项H(No」1B091),湖南省科技厅博士后科学基金(NO.2011RS4017),湖南省中医内科学和中西医结合基础垂点学科资助。favourablecurativeeffectonthetype2diabetesmellituswithnon-alcoholicfattyliver.Keywords:thetype2mellituswithnon-alcoholicfattyliver;liverfunction;ZiyinYiqiHuoxueJiedu0引言2型糖尿病（typeIIdiabe【esmelliuis,T2DM）可并发心脑血管、视网膜、肾脏、脂肪肝等病变。NAFLD与T2DM的关系密切，髙达75%的T2DM患者伴有NAFLD⑴。2010年,LianePorepa等的研究表明成人新诊糖尿病患者的晚期肝病（糖尿病性肝病）的发病风险增加⑵。迄今还未找到治疗脂肪肝的特效中西纱物，为了探讨中纱治疗2型糖尿病合并脂肪肝的方法，本研究用滋阴益气活血解毒法治...