内皮素、胰高血糖素及肝硬化食管静脉曲张再出血关系探析;作者：杨根妹，彭雪莲，王晓春，林颖，张忠兵毕业论文【关键词】；肝硬化；食管静脉曲张破裂再出血；，内皮素；胰高血糖素毕业论文［摘要］;目的；探讨内皮素-l(ET-l)和胰高血糖素(GL)与肝硬化食管静脉曲张破裂再出血的关系。方法；31例肝硬化食管静脉曲张破裂出血住院患者中，18例1周内再次出血(再出血组)，13例未再出血(未再出血组)。用放射免疫法分别测定两组患者在不同情况下血清内皮素和胰高血糖素浓度。结果；再出血组患者的血清内皮素和胰高血糖素浓度［(101.28±22.88)pg/L和(209.89±32.50)pg/L］明显高于未再出血组［(60.38±5.78)pg/L和(172.92±16.39)pg/L］,P&lt；0.05；再出血组中，肝功能ChildPughC级两者［(108.07土18.42)pg/L和⑵8.93±27.55)pg/L］明显高于B级L(67.33±1.53)pg/L和(164.67±5.77)pg/L］,P&lt；o.05；并且重度食管静脉曲张患者的血清内皮素和胰髙血糖素浓度［(101・28±22.88)pg/L和(209.89±32.5)pg/L］明显高于未再出血组的重度食管静脉曲张患者L(59.95±7.19)pg/L和(179.71±10.43)pg/L],P&lt；o.05o结论；血清内皮素、胰高血糖素显著升高可作为预测肝硬化食管静脉曲张破裂近期再出血的监测指标之一。毕业论文;[关键词];肝硬化；食管静脉曲张破裂再出血；内皮素；胰高血糖素毕业论文Studiesontherelationshipbetweenendothelinl,glucagon；andesophagealandgastricvaricesrebleeding；incirrhosis毕业论文；[Abstract]；Objective；Toexploretherelationshipbetween；endothelini,glucagonandesophagealandgastricvaricesrebleedingincirrhosis・Methods；Theserailevelsofendothelinl,glucagonsfrom31inpatientsofcirrhosiswithesophagealandgastrievaricesbleeding,amongthem,18patientswithrebleedinginoneweek(rebleedinggroup),13withoutrebleeding(nonrebleedinggroup)weredetectedbyradioimmunoassay(RIA)indifferentconditions.ResuIts；Theserumlevelsofendothelinlandglucagoninrebleedinggroup[(101.28土22.88)pg/Land(209.89±32.50)pg/L]weresignificantly；higherthanthatinnonrebleedinggroup[(60.38±5.78)pg/Land(172.92±16.39)pg/L],P&lt；0・05.Inrebleedinggroup,theconcentrationsofendothilinlandglucagonin；thepatientswithch订dPughC[(108.07±18.42)pg/Land(218.93±27.55)pg/L]weremarkedlyhigherthanthatinthe；patientswithchildpughB[(67.33±1.53)pg/Land(164.67±5.77)pg/L],P&It；0.05.Theconcentrationsofendothilinlandglucagonin；thepatientswith；severeesophageal；andgastricvaricesinrebleedinggroup[(101.28±22.88)pg/Land(209.89±32.5)pg/L]alsoweresignificantlyhigherthanthatinnonrebleedinggroup[(59.95±7.19)pg/Land(179.71±10.43)pg/L],P&It；0.05.Conclusion；Theincreasedlevelsofendothelinland；glucagoncouldbe；possiblyusedasamarkerforevaluatingtherebreeding；inthecirrhoticpatientswithesophagealandgastrie；varicesbleeding.毕业论文；[Keywords]cirrhosis；esophagealvaricesrebleeding；endothelinl；glucagon毕业论文;食管静脉曲张破裂出血是肝硬化的严重并发症之一，死亡率达30%〜50%,1周内再出血死亡率髙达60%以上[l]o临床上虽研究预测食管静脉曲张破裂出血方法很多，但结果不一[2]。临床上尤其缺乏对预测近期内再出血的有效指标。本研究拟探讨内皮素和胰高血糖素与肝硬化食管静脉曲张破裂再出血危险因子的相关性。毕业论文;1;资料与方法毕业论文;1.1;一般资料；收集我院消化科病房1998〜2006年期间，因上消化道出血住院的肝硬化患者31例。入院时均经内镜、腹部B超和肝功能等检查确诊为失代偿期肝硬化伴食管胃底静脉曲张破裂出血，并且排除消化性溃疡及胃癌。毕业论文冃镜下根据中华医学会消化内镜分会食管胃底曲张静脉内镜下诊断和治疗规范标准将其严重程度分为轻、中、重度三级。肝脏综合功能根据ChildPugh分级法分成A、B和C级。其中，1周内再出血18例，男10例，女8例，平均年龄为(552±9.3)岁。未再出血1...