立体定向伏隔核毁损术治疗酒精依赖患者术后健康状况及生存质量调[摘要]目的调查立体定向伏隔核毁损术治疗酒精依赖患者术后健康状况及生存质量。方法选择在第四军医大学唐都医院行立体定向伏隔核毁损术治疗酒精依赖患者31例为研究对象，术后1年对患者进行随访调查，了解患者术后的健康状况以及生存质量，分析该手术方法的安全性和有效性。结果1年内戒断率90.3%（28/31）。治疗后自我感觉健康状况较术前良好19例，占61.3%，感觉较术前好了一些10例，占32.3%，觉得和术前差不多2例，占6.5%，无自我感觉健康状况较术前差的患者。健康状况问卷调查结果显示患者术后12个月生理机能、生理职能、躯体疼痛、一般健康状况、情感职能、精神健康等各领域得分均较术前显著升高（P<0.01）。世界卫生组织生存质量测定量表简表调查结果显示术后患者生理领域、心理领域、社会关系领域、一般健康状况、生存质量领域得分及自我生存质量评分均较术前显著升高（P<0.01）。结论立体定向伏隔核毁损术治疗酒精依赖具有较好的临床疗效，能够显著改善患者的健康状况以及生存质量。[关键词]立体定向伏隔核毁损术；酒精依赖；健康状况；生存质量[]R749.62[文献标识码]B[]1673-9701（2015）09-0060-03AsurveyonpostoperativehealthconditionsandlifequalityforpatientswithalcoholdependencetreatedbystereotacticlesioningofnucleusaccumbensZHANGWei1HUANGZiye1SHA激anmin1GAOGuodong2DU激ang31.DepartmentofPsychiatry，WenzhouSeventhPeople'sHospital，Wenzhou325006，China；2.DepartmentofNeurology，TangduHospitaloftheFourthMilitaryMedicalUniversity，Xi’an710038，China；3.DepartmentofNeurology，ShanghaiMentalHealthCentre，Shanghai200030，China[Abstract]ObjectiveToinvestigatepostoperativehealthconditionsandlifequalityforpatientswithalcoholdependencetreatedbystereotacticlesioningofnucleusaccumbens.MethodsAll31patientswithalcoholdependencewhoreceivedstereotacticlesioningofnucleusaccumbensinTangduHospitaloftheFourthMilitaryMedicalUniversitywereselectedasresearchsubjects.Follow-upinvestigationwascarriedoutforpatientsoneyearafterthesurgery.Patients'postoperativehealthconditionsandlifequalitywereunderstood，soastoanalyzethesafetyandeffectivenessofthesurgicalprocedure.ResultsTheabstinenceratewithinoneyearwas90.3%（28/31）.19patientsfeltthattheirhealthconditionsafterthesurgeryweremuchbetterthanthosebeforethesurgery，accountingfor61.3%ofthetotalpatients.10patientsfeltthattheirhealthconditionsafterthesurgeryweresomewhatbetterthanthosebeforethesurgery，accountingfor32.3%ofthetotal.2patientsfeltthattheirhealthconditionswerethesameasthosebeforethesurgery，accountingfor6.5%ofthetotal.Nopatientsfeltthattheirhealthconditionswereworsethanthosebeforethesurgery.Resultsofthequestionnaireonhealthconditionsshowedthatscoresofphysiologicalfunction，rolephysical，physicalpain，generalhealthcondition，roleemotional，mentalhealthandotherdomainswithin12monthsafterthesurgerywereallsignificantlyhigherthanthosebeforethesurgery（P<0.01）.ResultsofWHOQualityofLife-BREFshowedthatscoresofphysicaldomain，psychologicaldomain，socialrelationdomain，generalhealthconditionandlifequalitydomainafterthesurgerywereallsignificantlyhigherthanthosebeforethesurgery（P<0.01）.ConclusionStereotacticlesioningofnucleusaccumbensinthetreatmentofalcoholdependencehasafavorableclinicaleffect，andiscapableofsignificantlyimprovingpatients'healthconditionsandlifequality.[Keywords]Stereotacticlesioningofnucleusaccumbens；Alcoholdependence；Healthconditions；Lifequality酒精依赖是长期滥用酒精导致的一种慢性中枢神经功能紊乱，主要表现为患者对酒精渴求以及强迫性的饮酒行为[1，2...