支气管哮喘患儿治疗前后血清IL-5、IL-10及肺功能变化临床探究［摘要］目的探讨支气管哮喘患儿应用孟鲁司特治疗前后血清白介素-5（IL-5）、白介素TO（IL-1O）及肺功能的变化，进一步为支气管哮喘的治疗方法提供指导依据。方法90例支气管哮喘患儿随机分为研究组和对照组各45例，两组均给予抗炎、吸氧、解痉、平喘等常规对症支持治疗，研究组在上述治疗的基础上联用孟鲁司特进行治疗，应用统计学方法对比分析两组的疗效，临床症状、体征改善情况以及治疗前后血清IL-5、IL-10及肺功能的变化情况。结果研究组的总有效率明显高于对照组（PVO.05）。研究组临床症状、体征消失时间均短于对照组（PV0.05）。研究组IL-5降低程度较对照组更明显（P<0.05）,而IL-10较对照组升高更明显（PV0.05）。两组的FEV1、FEV1/FVC.FEV1占预计值均较治疗前明显升高，且研究组肺功能改善程度较对照组更明显（PV0.05）。结论支气管哮喘患儿应用孟鲁司特治疗疗效确切，可以明显改善患儿的临床症状及体征，改善患儿的肺功能，考虑可能是孟鲁司特通过上调IL-10,抑制炎症因子口-5而发挥作用的。［关键词］支气管哮喘；孟鲁司特；血清IL-5；血清IL-10；肺功能［中图分类号］R562.2+5［文献标识码］B［文章编号］1673-9701(2011)32-33-03SerumIL-5,ILTOandLungFunctionbeforeandafterTreatmentfortheBronchialAsthmainChildrenGUOAihongDepartmentofPediatrics,CangnanCountyPeople"sHospitalinZhejiangProvince,Cangnan325800,China［Abstract］ObjectiveToexploretheapplicationofbronchialasthma,montelukasttreatmentinchildrenwithseruminterleukin-5(1L-5),Interleukin~10(ILTO)andchangesinlungfunction,furthertoprovideguidancebasedtreatmerit.MethodsAll90caseswithbronchialasthmawererandomlydividedintostudygroupandcontrolgroupof45patients.Twogroupsweregivenanti-inflammatory,oxygen,antispasmodic,generalsymptomaticandsupportivetreatmentsuchasasthma・Thestudygrouponthebasisoftheabovetreatmentscombinedwithmontelukasttreatment,theapplicationofstatisticalmethodstocomparetheefficacyofthetwogroups,clinicalsymptomsandsigns,aswe11asofserumIL-5,IL-10andlungfunctionchanges・ResultsThetotalstudygroupwassignificantlyhigherefficiency(P<0.05)・Twogroupspatientsaftertreatmentcough,wheezing,andlungwheezeandotherclinicalsymptomsandsignsweresignificantlyimproved,andtheclinicalsymptomsandsignsdisappearallthetimeofthestudygroupwasshorterthanthecontrolgroup(P<0.05)・TheserumIL~5oftwogroupsweresignifiesntlyreducedaftertreatment，andreducethelevelofresearchgroupsismoreobviousthaninthecontrolgroup(P<0.05)・IL—10aftertreatmentwassignificantlyhigherthanbeforetreatment,andthestudygroupthanthecontrolgroupincreasedmoresignificantly(PV0.05)・TwogroupsofpatientsaftertreatmentoftheindicatorsoflungfunctionsignificantlyimprovedaftertreatmentwhichthetwogroupsFEV1,FEV1/FVC,FEV1%predictedwassignificantlyhigherthanbeforetreatment,andresearchgroupstoimprovethedegreeoflungfunctionismoreobviousthaninthecontrolgroup(P<0.05)・ConclusionTheapplicationofbronchialasthma,montelukasttreatmentinchildreniseffective,cansignificantlyimprovetheclinicalsymptomsandsignsinchildren,andimprovelungfunctioninchildren,montelukastmaybeconsideredbytheincreasedILTO,inhibitionofinflamniatorycytokinesIL-5playarole・［Keywords］Bronchialasthma；Montelukast；SerumIL~5；SerumIL-10；Pulmonaryfunction儿童支气管哮喘是儿科的常见病、多发病，近年来其患病率逐年上升。哮喘的病因及发病机制目前尚不完全明确，目前已知哮喘发病与诸多炎症因子有关。近年来研究发现，血清白介素-5(IL-5)及白介素-10(IL-10)等细胞因子及炎症因子均以不同方式参与了支气管哮喘患儿发病的全过程［1］。本研究旨在探讨支气管哮喘患儿应用孟鲁司特...