ChenBao-lin,Professor,BureauofScienceTechnologyResearch,HulunbuirCollege,Hulunbuir021008,InnerMongoliaAutonomousRegion,ChinaCorrespondingauthor:ChenBao-lin,BureauofScienceTechnologyResearch,HulunbuirCollege,Hulunbuir021008,InnerMongoliaAutonomousRegion,ChinaAccepted:2016-05-07Surfaceconstructionandbiocompatibilityofpolymermaterialsascardiovasculardevices:modifiedtissue-engineeredendothelialcellsonthesurfaceofpolymericbiomaterialsChenBao-lin1,WangDong-an2,31BureauofScienceTechnologyResearch,HulunbuirCollege,Hulunbuir021008,InnerMongoliaAutonomousRegion,China2InstituteofPolymerScience,Zhe激angUniversity,Hangzhou310027,Zhe激angProvince,China3DepartmentofPharmaceuticalSciences,UniversityofTennesseeHealthScienceCenter,Memphis,Tennessee38163,USACitethis:ChenBL,WangDA.Surfaceconstructionandbiocompatibilityofpolymermaterialsascardiovasculardevices:modifiedtissue-engineeredendothelialcellsonthesurfaceofpolymericbiomaterials.ZhongguoZuzhiGongchengYan激u.2016;20(30):4515-4523.DOI:10.3969/j.issn.2095-4344.2016.30.016ORCID:0000-0001-8283-783X(ChenBao-lin)AbstractBACKGROUND:Asthecardiovasculardevice,biomaterialsappliedundertheblood-contactconditionsshouldhaveanti-thrombotic,anti-biodegradableandanti-infectiveproperties.OBJECTIVE:Toreviewtheresearchprogressioninpolymermaterialsforimplantationandinterventionincardiovasculartissueengineeringandtoexplorethebiocompatibility,bloodcompatibilityandcytocompatibilityofthesurface-modifiedpolymerbiomaterialsbasedonthesurfaceendothelializationusingtissueengineeringtechniques.METHODS:WeretrievedPubMedandWanfangdatabasesforrelevantspublishingfrom1963to2015.Thekeywordswere“Biocompatibility,Bloodcompatibility,BiomedicalMaterials,Biomedicalpolymermaterials”inEnglishandChinese,respectively.Thoseunrelated,outdatedandrepetitivepaperswereexcluded.Literaturesaddressingthebloodcompatibility,biocompatibility,andcytocompatibilityofthesurface-modifiedpolymerbiomaterialsbasedonthesurfaceendothelializationusingtissueengineeringtechniqueswereinvestigatedbysummarizingfunctionofvascularendothelialcells,tissue-engineeredendothelialcellsontheimplantsurface,fixationofcellgrowth-promotingfactoronthesurfaceofpolymericbiomaterials,andendothelializationofthematerialsurface.RESULTSANDCONCLUSION:Totally71relevantswereincluded.Thetissue-engineeredmodificationofendothelialcellsonthesurfaceofpolymerbiomaterialsandtheirbiocompatibilityandcellcompatibilityarecrucialfordevelopingnovelpolymermaterialsforimplantationandinterventionincardiovasculartissueengineering.Throughin-depthstudiesofthetypesandapplicationsofpolymerbiomaterials,cardiovascularmedicaldevicesandimplantablesofttissuesubstitutes,thedifferencesbetweenthesurfaceandthebodywillbereflectedinthemanylayersofmoleculesextendingfromthesurfacetothebody.Twomajorfactors,surfaceenergyandmolecularmobility,determinethebody/surfacebehaviorsthatincludebody/surfacedifferencesandphaseseparation.Consideringthedifferencebetweenthebody/surfacecomposition,anadditionaldeterminantisindispensable,thatis,thecrystallizationbehaviorofeachcomponent.Subjectheadings:BiocompatibleMaterials;TissueEngineering;EndothelialCells---本文于网络，仅供参考，勿照抄，如有侵权请联系删除---INTRODUCTIONBiocompatibilityisanimportantproblemintheclinicalapplicationofbiomaterials.Seeding,culturingcells,andpreparingpolymerssuitableforcellgrowt...