温胆汤加味联合黛力新治疗难治性功能性消化不良伴睡眠障碍的效果【摘要】目的探?分析温胆汤加味联合氟哌噻吨美利曲辛片（黛力新）治疗难治性功能性消化不良伴睡眠障碍的临床效果。方法80例难治性功能性消化不良伴睡眠障碍患者，随机分为中药治疗组以及参照组，每组40例。参照组给予莫沙必利联合黛力新治疗，中药治疗组给予温胆汤加味联合黛力新治疗。实验结束后，对比分析两组患者治疗前后的症状评分、临床疗效以及不良反应发生情况。结果治疗前两组患者症状评分比较差异无统计学意义（P>0.05）；治疗后中药治疗组症状评分低于参照组，差异具有统计学意义（P<0.01）。中药治疗组治疗总有效率为97.5%，参照组治疗总有效率为82.5%，中药治疗组总有效率高于参照组，差异具有统计学意义（P<0.05）。中药治疗组不良反应发生率为5.0%，参照组不良反应发生率为20.0%，中药治疗组不良反应发生率低于参照组，差异具有统计学意义（P<0.05）。结论温胆汤加味联合黛力新治疗难治性功能性消化不良伴睡眠障碍可取得显著的治疗效果，其疗效持久，安全性较高，不良反应较少，值得临床推广应用。【关键词】温胆汤加味；氟哌噻吨美利曲辛片；难治性功能性消化不良；睡眠障碍；临床效果DOI：10.14163/jki.11-5547/r.2017.16.008ObservationoneffectofmodifiedWendandecoctioncombinedwithDeanxitinthetreatmentofrefractoryfunctionaldyspepsiacomplicatedwithsleepdisordersLIUYan-min，CEHNMin，FUDao-shi.GuangzhouCityHuangpuDistrictScienceandTechnologyBureau，Guangzhou510760，China【Abstract】ObjectiveToexploreandanalyzetheclinicaleffectofmodifiedWendandecoctioncombinedwithflupentixolandmelitracentablets（Deanxit）inthetreatmentofrefractoryfunctionaldyspepsiacomplicatedwithsleepdisorders.MethodsAtotalof80patientswithrefractoryfunctionaldyspepsiaandsleepdisorderswererandomlydividedintotraditionalChinesemedicinetreatmentgroupandcontrolgroup，with40casesineachgroup.ThecontrolgroupreceivedmosapridecombinedwithDeanxitfortreatment，andthetraditionalChinesemedicinetreatmentgroupreceivedmodifiedWendandecoctioncombinedwithDeanxitfortreatment.Afterexperiment，comparisonandanalysisweremadeonsymptomscorebeforeandaftertreatment，clinicalcurativeeffectandadversereactionsoccurrenceintwogroups.ResultsBeforetreatment，bothgroupshadnostatisticallysignificantdifferenceinsymptomscore（P>0.05）.Aftertreatment，thetraditionalChinesemedicinetreatmentgrouphadlowersymptomscorethanthecontrolgroup，andthedifferencehadstatisticalsignificance（P<0.01）.ThetraditionalChinesemedicinetreatmentgrouphadtotaltreatmenteffectiverateas97.5%，whilethecontrolgrouphadtotaltreatmenteffectiverateas82.5%.ThetraditionalChinesemedicinetreatmentgrouphadhighertotaleffectiveratethanthecontrolgroup，andthedifferencehadstatisticalsignificance（P<0.05）.ThetraditionalChinesemedicinetreatmentgrouphadincidenceofadversereactionsas5.0%，whilethecontrolgrouphadincidenceofadversereactionsas20.0%.ThetraditionalChinesemedicinetreatmentgrouphadlowerincidenceofadversereactionsthanthecontrolgroup，andthedifferencehadstatisticalsignificance（P<0.05）.ConclusionCombinationofmodifiedWendandecoctionandDeanxitshowssignificanttherapeuticeffectintreatingrefractoryfunctionaldyspepsia，anditshowslastingcurativeeffect，highsafetyandfewadversereactions.Soitisworthyofclinicalpopularizationandapplication.【Keywords】ModifiedWendandecoction；Flupentixolandmelitracentablets；Refractoryfunctionaldyspepsia；Sleepdisorders；Clinicaleffect难治性功能性消化不良是临床常见的疾病类型，患者主要表现出恶心呕吐、反酸纳呆以及餐后饱胀的症状，对其正常的生活以及身体健康造成了严重的影响[1]...