大连医科大学硕士学位论文UDCA（优思弗）治疗脂肪性肝病的临床疗效观察姓名：刘林申请学位级别：硕士专业：内科学指导教师：王英徳201106删鼬1砸思弗舫淪獅I腌临牀病的胞嚴疗效观察硕士生姓名：刘林指辱魏帕阀縫教濒授指导邢缠：朧核教歆授专'昨徹内耕荐学目的：脂肪性肝病是一种日益多发的慢性肝脏疾病。本研究采用熊去氧胆酸（商品名：UDCA优思弗）治疗脂肪性肝病患者，观察熊去氧胆酸治疗脂肪性肝病的疗效，包括临床症状、肝功能、血脂及影像学变化的情况。方法：选择诊断明确的脂肪性肝病患者30例，口服UDCA13-15mg/kg/d,分B树飜勰鵬般勉谿I觎嚓临疣症狒取善情阪丿腳葩睫自豹制皺观察肝功能与血脂指标的变化，B型超声检测肝脏影像学变化。结果：30例患者治疗6周后，72.7%的患者消化道症状消失，79.3%的患者瘙痒消失，87%的患者黄疸症状消失；肝功能（ALT、AST、GGT、ALP）及血脂（TC、DW劇咖融翱爛羁翩t趙贩陶显圈的帥隸意刘防删5）,而没发现明显的副作用，但B型超声检查显示治疗前后肝脏影像学无明显变化。对指标治疗曲线变化情况分析的结果表酬备令蠶融曲绷甫乔凰的特征，'細厢郦傲曲线斜率有不同程度的变化，其中血呈加蚩均羽践性（W、T谩呈快、慢、较帧™翹势。潞疗）荡周的翩孵为癞瞬锄率却脚笊斷W敷率为83.4%o结论：熊却胆酸能够翎隔瞬肪熾脯病患曆的临床症痂丁脯瑰能5以及血脂等指标，临床上可以安全有数地治疗脂肪性肝病。关键词：熊去氧胆酸脂肪性肝病疗效TherapeuticEfficacyofUrsodeoxycholic科神fUDCA)inTreatmentofFattyLiverDiseaseMaster^pgreecsndMate:LiuLinSupervisor:ProfessorWangYing-dey^Tsppenfipor:TangHai-yingMajor:GastroenterologyAbstractObjective:Fattyliverdisease(FLD)isachronicliverdiseasewithanincreasingmorbidity^InthfeTsfiKiyjiWTsodeoxycholicacid(UDCA)wasusedtotreatpatientswithFLDinordertoobserveitstherapeuticefficacyonclinicalsymptoms,liverfunctions,serum丽dsandimagingparameters.Methods:30patientswithconfirmedFLDwereselected.OraladministrationofVpCA(13・1軒彌俺的)，3timesperdayfor6weeks,wascarriedouttoobservetheimprovementoftheclinicalsymptoms;automaticbiochemicalimaginganalyzerwasusedtoexamthelivefunctionsandserumlipids,and隔typeidfiBSoundwasemployedtoobservetheimagingpw^rpeters.Results:After6TWeektreatment,72.7%ofthepatientswithgastrointestinalsymptoms,79.3%withitchingand87%with强showedasignificantlyimprovement.Allthesixparametersinliverfunction(ALT,AST,GGT,ALP)andserumlipidtests(TC,TG)observedinthisstudyshowedasignificantdecreaseafterasignificantstatisticaldifference(P<0.05),NosideeffectsofUDCAwereobservedduringthetreatmentpppo^jB-typeuitfSBoundexaminationStowedthattheimagingparametershadnochangesaftertreatment.Analysisontheparameters'curveEhowdthatthecurveofeachparameterhasitsdifferentcharaatBristfas.Differenttreatmentstagehasdifferentpatternsofslopechanges,inwhichbbthALTandASTpresenteduniformtinwTdqciine,whileTGhasHst^TJIH^Tlndmoderatedecline.Statisticalanalysisthatthesignificanteffectiveratewas36.7%;theefifectiveratewas46.7%andtheoveralleffectiveratewas83.4%aftertreatment.Conclusion:Ursodeoxycholicacid(UDCA)isabletosignificantlyimprovetheclinicalsymptoms,liverfiinctionsandserum［雨idsinpatients斯thFLD>Therefore,itcc甌cccc,ccanbeeffectivelyandsafetyusedintheclinicaltreatmentofFLD.Key豌丽fattyliverdisease,UDCA,efficacy在大连医科大学攻读（博士、学位期间在导师指导下完成的学美手学位诒文使用敝瞬明《UTO汎优制拂制树月鼬I翩船血现察》系本人位论文。知辺膽寻删喘金了懈極剛离蹄屏砂徂论文的规定，同意学校保留并向有关部门或机构送交学位论文的复印件和电子版本，允许论文被查阅和借阅，同意学校将本论文加入:1・中国学术期刊（光盘版）电子杂志社一《中国博士学位论文全'文数据库...