小剂量柳氮磺胺毗噪口服、丹参注射液静滴联合六神丸、云南门药保留灌肠治疗溃疡性结肠炎的临床应用探讨作者：林少忠，刘思徳单位：广东佛山，佛山市顺徳区勒流医院【摘要】目的探讨小剂量柳氮磺胺毗噪(SASP)口服、丹参注射液静滴联合六神丸、云南白药保留灌肠治疗活动期轻中度溃疡性结肠炎的临床疗效。方法83例病人随机分为治疗纽•和对照纽，治疗组44例，SASP(0.5g,4次/d,口服)，丹参注射液20ml加入5%葡萄糖静滴联合六神丸、云南白药保留灌肠，不用激素、免疫抑制剂及止痛、止泻药物；对照组39例SASP(l.Og,4次/d,口服)及庆大霧素、思密达保留灌肠。疗程8周。观察两组临床效果、结肠镜下黏膜改变、肠黏膜病理组织学变化及药物不良反应。结果治疗纽.44例、对照纽39例完成观察和随访。治疗纽•在临床疗效、结肠镜下黏膜改变、肠黏膜病理纽织学改变方面均优于对照纽(前者有效率分别为93.18%、95.45%、95.45%)。不良反应低于対照组。结论小剂竄SASP口服、丹参注射液静滴联合六神丸、云南白药保留灌肠治疗溃疡性结肠炎具有疗效好，应用方便，提高溃疡愈合，副作用少的优点，值得临床推广。【关键词】溃疡性结肠炎；柳氮碱胺毗噪；六神丸；云南白药；灌肠治疗ClinicalapplicationofsmalldoseSASP,DansheninjectioncombinedwithLiushenpill,YunnanwhitepowderretentionenematocureulcerativecolitisLINShao-zhong,LIUSi-de.LeiliuHospitalofShundeDistrictinFoshan,Guangdong528322,China[Abstract]ObjectiveToapproachtheclinicaltherapeuticeffectsonlightormid-rangeulcerativecolitisbysmalldosesulfasalazine(SASP)Qanshenrootinjection,associationwithLiushenpill.MethodsEighty-threepatientswererandomlydividedintotreatmentgroupandcontrolgroup.Thetreatmentgroup(n=40)wastreatedwithSASP(0.5g,4timesperdayfororaluse),Dansheninjection(20mladdedin5%glucose)combinedwithLiushenpill,Yunnanwhitepowderretentionenema.therewerenotimmunosuppressiveagent,odynolysisandconstipatingremedyforuse;thecontrolgroup(n=39)wastreatedSASP(1.0,4timesperdayfororaluse)combinedwithgentamycinandsmectiteretentionenema,thecourseoftreatmentwere8weeks,weobservedthetwogroupstherapeuticeffects,themucosachangeundercolonoscope,bowelmucosapathohistologychangesanddrugadversereaction.ResultsThetwogroupswereallobservedandibllowed-up,thetreatmentgroupontherapeuticeffect,themucosachangeundercolonoscopeandbowelmucosapathohistologychangewerehigherthanthatofthecontrolgroup(theformerefficiencywere93.18%、95.45%95.45%)，andadversereactionwaslowerthanthatofthecontrolgroup.ConclusionTherearealotofmeritsforsmalldoseSASP,Dansheniiijectioncombinedwithsixspiritspill,Yunnanwhitepowderretentionenematocureulcerativecolitissuchasgoodtherapeuticeffect,applicationconvenience,highulcerationhealingandminoradversereactionjtdeservesgeneralization.[Keywords]ulcerativecolitis;sulfasalazine;Liushenpill;Yunnanwhitepowder;retentionenema溃疡性结肠炎是消化内科常见病，主耍累及左半结肠和直肠，少数侵犯全结肠，其发病机制尚不十分明了，可能与感染、自身免疫、精神以及遗传等因素有关[1]。病程反复，应用帘规剂最柳氮磺胺毗噪及激素治疗副作用大。笔者采用小剂量SASP口服、丹参注射液静滴联合中药灌肠治疗活动期轻中度溃疡性结肠炎，取得较好疗效，现报告如下。1对象与方法L1研究対象83例均为门诊及住院患者，经过临床症状、结肠镜检杏、纽织病理学检查确诊为活动期轻和中型UC,符合中华医学会2001年制订的诊断标准，均尢炎症性息肉形成等慢性期表现，经普通细菌学及寄生虫检查阴性。除外妊娠或哺乳期、严重全身疾病、肝病、对磺胺及水杨酸类过敏者。随机分为治疗组44例,对照组39例。治疗组男35例,女9例,年龄24〜62岁，平均43.6岁，病程2.5〜5年，初发12例，复发32例；直乙结肠炎28例，左半结肠炎15例，全结肠炎1例；英中轻型13例，中型3...