江苏大学学报(医学版)JournalofJiangsuUniversity(MedicineEdition)2型糖尿病患者平均动脉压与臂踝脉搏波传导速度的相关性张盼盼，赵丽，邓霞，邱悦，陈珂，吴旭楠，袁国跃，杨玲，王东(江苏大学附属医院内分泌代谢科，江苏镇江212001)［摘要］目的：探讨2型糖尿病(T2DM)患者平均动脉压(MAP)与臂踝脉搏波传导速度(BaPWV)的相关性。方法：选取T2DM患者979例，应用电子血压计测量患者右上臂血压，计算MAP,采用三分位数法分为低MAP组(MAP<92.4mmHg,n=327),中MAP组(92.4mmHgWMAP<102.4mmHg,几=326),高MAP组(MAPN102.4mmHg,n=326)0应用欧姆龙动脉硬化检测仪测定BaPWV及踝肱指数。采用多元线性回归及Ix^stic回归模型分析MAP与BaPWV的相关性。绘制ROC曲线评估MAP对T2DM患者发生动脉硬化的预测价值。结果：T2DM患者随着MAP增加BaPWV逐渐升高(P<0.01)。相关分析显示,T2DM患者MAP与年龄、体重指数、腰臀比、胰岛素抵抗指数、三酰甘油>BaPWV呈正相关。线性回归显示，在校正相关危险因素后,MAP与BaPWV仍呈正相关(P<0.01)。Logistic回归分析显示，校正其他混杂因素后MAP与T2DM患者BaPWV独立相关(OR为1.160,95%CZ：1.132~1.188)。MAP预测T2DM患者发生动脉硬化的ROC曲线下面积为0.786(95%C7：0.759-0.811,P<0.01)，最佳临界值为94.4mmHg(敏感度为75.0%，特异度为69.2%)。结论：MAP有望成为预测T2DM患者动脉硬化风险的简易实用的指标。［关键词］2型糖尿病;动脉硬化;臂踝脉搏波传导速度;平均动脉压［中图分类号］R543.5;R587.1［文献标志码］A［文章编号］1671-7783(2021)03-0190-06DOI：10.13312/j.issn.1671-7783.y210050［引用格式］张盼盼，赵丽，邓霞，等.2型糖尿病患者平均动脉压与臂踝脉搏波传导速度的相关性［J］.江苏大学学报(医学版),2021,31(3):190-195,199.Correlationbetweenmeanarterialpressureandbrachial-anklepulsewavevelocityinpatientswithtype2diabetesmellitusZHANGPanpan,ZHAOLi,DENGXia,QIUYue,CHENKe,WUXunan,YUANGuoyue,YANGLing,WANGDong(DepartmentofEndocrinology,AffiliatedHospitalofJiangsuUniversity,ZhenjiangJiangsu212001,China)［AbstractJObjective:Toexplorethecorrelationbetweenmeanarterialpressure(MAP)andbrachial-anklepulsewavevelocity(BaPWV)inpatientswithtype2diabetesmellitus(T2DM).Methods；Ato-talof979patientswithT2DMwererecruitedforthisstudy.Electronicsphygmomanometerwasusedformeasuringbloodpressureintherightarms,andMAPwascalculated.BasedonMAP,patientsweredi-videdintolowMAPgroup(MAP<92.4mmHg,n=327),mediumMAPgroup(92.4mmHgWMAP<102.4mmHg,n=326)andhighMAPgroup(MAPN102.4mmHg,n=326).TheBaPWVandankle-brachialindexweremeasuredbyOmronarteriosclerosisdetector.ThecorrelationbetweenMAPandBaP-WVwereevaluatedbymultiplelinearregressionanalysisandLogisticregressionanalysis.TheROCcurveofMAPwasdrawntoevaluateitspredictivevalueforarterialstiffnessinT2DM.Results：BaPWVlevelwasgraduallyelevatedwithMAPinT2DMpatients(P<0.01).CorrelationanalysisindicatedthatMAPwaspositivelycorrelatedwithage,bodymassindex,waist-to-hipratio,insulinresistanceindex,triglyce-ride,andBaPWV.MultiplelinearregressiondemonstratedthatMAPwaspositivelyassociatedwithBaP-［基金项目］国家自然科学基金资助项目(81870548,81570721)；江苏省社会发展(重点研发)项目(BE2018692)；江苏省自然科学基金资助项R(BK20191222)；江苏省卫生计生委科研谡题(Y2018109)；镇江市重点研发计划(社会发展)项R(SH2019041)［作者简介］张盼盼(1994-),女,硕士研究生;王东(通讯作者)，主任医师，硕士生导师,E-mail：zjdongdonghao@aliyun.comWVafteradjustmentforassociatedriskfactors(P<0.01).LogisticregressionanalysisshowedthatMAPwasindependentlyassociatedwithBaPWVinT2DMpatientsafteradjustmentforotherconfbunders(OR=1.160,95%CI：1.132-1.188).TheareaundertheROCcurveofMAPforpredictingarterialstiffnesswas0.786(95%...