已上市中成药治疗糖尿病的用药规律及核心处方挖掘杨亚男李艳杰陈玉鹏倪青---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除------本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除------本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除------本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除------本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除------本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---Summary目的：通过数据挖掘研究已上市中成药治疗糖尿病的用药规律及核心处方，为临床更好地治疗糖尿病和新药研发提供新思路。方法：从2020版《中华人民共和国药典》及药智网“中成药处方数据库”中查找“消渴”“糖尿病”等Key，找出治疗糖尿病的中成药处方并建立数据库，通过Excel、中医医---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---案知识服务共享系统、复杂网络分析软件（Liquorice软件）对所涉及中药进行归纳分析。结果：共纳入中成药71种，涉及中药158味，得出了这些药物的用药频次、性味归经特征及组方规律;得到71种中成药的核心处方;主要证型为气阴两虚证、气阴两虚兼内热、阴虚内热、气阴两虚兼血瘀、阴虚燥热兼气虚血瘀证，并分别得到5个证型的核心处方及相应配伍。结论：通过运用数理统计方法对已上市治疗糖尿病的中成药进行组方分析，得出其用药规律及和核心处方，可为指导临床用药及新药研发提供参考。Key糖尿病;中成药;复杂网络;关联规则;用药规律;配伍;核心处方;数据挖掘MedicationRegularityandCorePrescriptionsofMarketedChinesePatentMedicinesAgainstDiabetesYANGYanan1，LIYan激e2，CHENYupeng2，NIQing1（1Guang′anmenHospital，ChinaAcademyofChineseMedicalSciences，Bei激ng100053，China;2GraduateSchoolofBei激ngUniversityofChineseMedicine，Bei激ng100032，China）AbstractObjective：ToinvestigatethemedicationregularityandcoreprescriptionsofmarketedChinesepatentmedicinesagainstdiabetesbydatamininginordertoprovidereferencesforclinicaltreatmentofdiabetesandnewideasfornewdrugdevelopment.Methods：TheChinesePharmacopoeia（2020）andYaozhweresearchedforprescriptionsofChinesepatentmedicineagainstdiabeteswithkeytermsof“consumptivethirst”and“diabetes”andthedatabasewasestablished.CrudedrugsinvolvedweresummarizedandanalyzedthroughExcel，TCMKnowledgeServiceandSharingSystem，andLiquorice.Results：Seventy-oneChinesepatentmedicineswereincluded，involving158crudedrugs.Thefreq---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---uencyofuse，properties（nature，flavor，andmeridiantropism），andcompatibilityofthesedrugswereobtained.Thecoreprescriptionsof71crudedrugswerescreenedoutbycomplexnetworkanalysis.Asrevealedbysyndromeclassificationofincludedprescriptions，themainsyndromesincludedqi-yindeficiency，qi-yindeficiencyandinternalheat，yindeficiencyandinternalheat，qi-yindeficiencyandbloodstasis，andyindeficiency-generatedinternalheatcombinedwithqideficiencyandbloodstasis，andthecorrespondingcoreprescriptionswereobtained.Conclusion：ThroughtheanalysisofprescriptionsofChinesepatentmedicinesmarketedforthetreatmentofdiabetesbymathematicalstatisticsmethods，themedicationregularityandcoreprescriptionscanbeobtained，whichcanprovideideasforclinicalmedicationandthedevelopmentofnewdrugs.KeywordsDiabetes;Chinesepatentmedicine;Complexnetworks;Associationrule;Medicationregularity;Compatibilityofdrugs;Coreprescription;Datamining中圖分类号：R259：Adoi：10.3969/j.issn.1673-7202.2022.03.022糖尿病是一種以持续性高血糖为主要表现，以胰岛素抵...