微生态制剂、蒙脱石散剂、干扰素三联法治疗小儿秋季腹泻临床疗效观察［摘要］目的观察微生态制剂、蒙脱石散剂、干扰素三联法治疗小儿秋季腹泻的临床疗效。方法将84例患儿按随机数字表分为观察组42例和对照组42例，对照组口服蒙脱石散剂冲剂，肌内注射重组人干扰素，观察组在对照组基础上，口服枯草杆菌、肠球菌二联活菌多维颗粒剂（妈咪爱）,2周岁者每次1〜2袋、1〜2次/d,3d为1个疗程，观察治疗前后患儿症状改善情况，计算患儿症状复常时间与出院时间。结果（1）观察组的治愈率、总有效率分别为61.90%、95.24%,对照组的治愈率、总有效率分别为28.57%、76.19%,观察组的治愈率、总有效率均明显高于对照组，差异具有统计学意义（P<0.05）；（2）观察组的退热、大便次数复常、大便性状复常、粪便镜检复常、平均出院时间较对照组均明显缩短，各项指标差异均具有统计学意义（P<0.05）。结论微生态制剂、蒙脱石散剂、干扰素三联法治疗小儿秋季腹泻临床疗效确切，可双向调节肠道菌群失调，改善肠道内环境，保护、修复受损黏膜，促进消化道上皮组织再生。［关键词］微生态制剂；蒙脱石散剂；干扰素；小儿秋季腹泻；临床应用［中图分类号］R975+.3［文献标识码］A［文章编号］1674-4721(2012)07(c)-0100-03Theeffectobservetionofprobiotics,montmorillonitepowderandinterferonintreatmentofinfantileautumndiarrheaYEZuowenPediatricsDepartment,ZijinCountyPeople"sHospitalofHeyuanCityinGuangdongProvince,Zijin517400,China[Abstract]ObjectiveToobservetheeffectofprobiotics,montmorillonitepowderandinterferoninthetreatmentofinfantileautumndiarrhea・MethodsEighty—fourpatientsweredividedintoobservetiongroup(42cases)andcontrolgroup(42cases),thecontrolgroupwasgivenmontmorillonitepowdergranulesandrecombinanthumaninterferonintramuscularinjection,theobservationgroupwasgivenbacillussubtilis,enterococcusbivalentviablemultidimensionalgranulesoralonthebasisofthecontrolgroup,patientswiththeage2yearsoldweregiven1~2bagsonce,1-2timesaday,bothgroupsweretreatedfor3daysforacourse,thesymptomswereobservedbeforeandaftertreatment,andthesymptomsrecovertimeanddischargetimewerecalculated・ResuIts(1)Thecurerateandthetotalefficiencyofobservationgroupwere61.90%and95.24%respectively,thatofthecontrolgroupwere28.57%and76.19%,thecurerateandtotalefficiencyoftheobservationgroupwassignificantlyhigherthanthatofthecontrolgroup,thedifferencewasstatisticallysignificant(P<0.05)；(2)Thetimeoffeverrecover,stoolfrequencynormalization,normalizationofstoolconsistency,stoolmicroscopynormalization,andtheaveragedischargetimeweresignificantlyshorterthanthoseofthecontrolgroup,thedifferenceswerestatisticallysignificant(P<0.05).ConclusionTheprobiotics,montmorillonitepowderandinterferonhasexactclinicalefficacyinthetreatmentofinfant订eautumndiarrhea,itcanbi-directionallyregulateintestinalflora,improvetheintestinalenvironment,protectandrepairdamagedmucosa,promotetissueregenerationofdigestivetractepitheliaL
