复方甲硝哇栓联合倍美力软膏治疗老年性阴道炎的临床研究复方甲硝陛栓联合倍美力软膏治疗老年性阴道炎的临床研究【摘要】目的：探讨复方甲硝哗栓联合倍美力软膏治疗老年性阴道炎的临床疗效和安全性。方法：选取2011年1月至2012年12月来本院妇科就诊的老年性阴道炎患者共130例作为研究对象。根据入院时间将患者随机分为观察组和对照组，每组各65人。对照组采用甲硝哇栓进行治疗，观察组加用倍美力软膏进行联合治疗。对比两组临床表现改善情况、血清激素水平和临床疗效。结果：治疗后，与对照组相比，观察组白带增多、阴道瘙痒和阴道壁红肿充血症状明显缓解(x2=4.33、4.01、6.39,P均<0.05)；治疗后，与对照组相比，观察组血清FSH水平升高幅度较大(U=8.43,P<0.05),E2降低幅度较大(U=5.59,P〈0.05)；观察组治愈率和总有效率分别为63.08%和95.38%,均高于对照组(44.62%,81.54%)(x2=4.46.6.10,P均<0.05)o结论：复方甲硝哩栓联合倍美力软膏治疗老年性阴道炎较单纯应用复方•甲硝哇栓具有明显的优势，给药方便，安全可靠，值得在临床上进一步推广。【关键词】老年性阴道炎；复方甲硝哩；倍美力软膏；临床疗效EffectofcompoundmetronidazolesuppositoriesandpremarinointmentonthetreatmentofsenilevaginitisZHANGQunhual,WuXiaofei1,CAOShuhua2.1.DepartmentofObstetrics,LinanCityPeople'sHospital,Hangzhou311300,China；2.DepartmentofObstetricsandGynecology,SecondHospitaiAffi1iatedtoWenzhouMedicalUniversity,Wenzhou311300,China[Abstract]Objectives：Toinvestigatetheclinicalefficacyandsafetyofcompoundmetronidazolesuppositoriesandpremarinointmentforthetreatmentofsenilevaginitis.Methods：130patientswithsenilevaginitishavingreceivedtreatmentintheDepartmentofGynecologyofourhospitalfromJanuary2011toDecember2012wereselectedasresearchobjects,andrandomlydividedintoobservationgroupandcontrolgroupaccordingtotheadmissiontime,eachof65patients.Patientsinthecontrolgroupweretreatedwithcompoundmetronidazolesuppositorieswhilepatientsintheobservationgroupreceivedthejointtreatmentofcompoundmetronidazolesuppositoriesandpremarinointment.Theclinicalimprovement,serumhormonelevelsandclinicalcurativeeffectofthe2groupswerecompared.Results：Aftertreatment,comparedwiththecontrolgroup,theleukorrhagia,vaginalitchingandswellingcongestionsymptomsofvaginalwallintheobservationgroupwereobviouslyalleviated(x2二4.33,4.01,4.33,P<0.05)；aftertreatment,comparedwiththecontrolgroup,theincreaseofserumFSHlevel(U=8.43,P<0.05)andthedecreaseofE2(U=5・59,P<0.05)intheobservationgroupweremuchlarger；thecurerateandtotaleffectiverateoftheobservationgroupwere63.08%and95.38%respectively,higherthanthecontrolgroup(44.62%,81.54%)(x2=4.46,4.46,P<0.05).Conclusion：Comparedwithusingcompoundmetronidazolesuppositoriesalone,thejointuseofcompoundmetronidazolesuppositoriesandpremarinointmentisofobviousadvantages,convenient,safeandreliable,andworthyoffurtherpromotion.[Keywords]Senilevaginitis；Compoundmetronidazolesuppositories；Premarinointment；Clinicalcurativeeffect<!—endprint—><!—startprint—>【】R711.31【文献标志码】A老年性阴道炎乂称之为萎缩性阴道炎，是老年女性常见的妇科病。国内外报道的发病率均在30%左右，近年来,随着人II老龄化的到来，发病率有上升的趋势。老年性阴道炎可引起外阴瘙痒、阴道干燥、灼痛、分泌物异味等多种临床症状，严重影响了老年女性的生活质量。既往研究显示，单独应用抗生素或雌激素治疗都不能达到理想的效果[1-3]o本研究采用复方甲硝陛栓联合倍美力软膏对老年性阴道炎进行了临床治疗，现将结果报告如下。1材料与方法1.1对象选取2011年1月至2012年12月来本院妇科就诊的老年性阴道炎患者共130例作为研究对象。年龄53~76岁，平均年龄（66.4±7.3）岁，绝经年限3~2...