正规维持疗法预防消化性溃疡穿孔术后复发的疗效观察[摘要]目的：探讨用4种治疗消化性溃疡的药物对胃十二指肠溃疡穿孔合并幽门狭窄患者术后进行正规维持治疗，观察其预防溃疡复发的临床功效。方法：将72例确诊为胃十二指肠溃疡穿孔合并幽门狭窄的患者随机分为两组：治疗组36例，患者行溃疡穿孔灶菱形切除联合幽门成形术，术后给予相关药物维持治疗（甲氰米胍或泮托拉唑），胃肠功能恢复后，改为正规维持治疗，奥美拉唑20～40mg/d，睡前一次服用，维持6个月；同时给予德诺（枸橼酸铋钾）240mg，每日2次，灭滴灵400mg，每日2次，阿莫西林500mg，每日2次，口服4周。对照组36例术后只给予相关药物维持治疗，并对两组进行疗效观察。结果：治疗组36例患者无嗳气、反酸、腹胀、呕吐现象，均痊愈出院，半年常规复查胃镜，显示溃疡愈合，幽门通畅，且随访期间无溃疡症状复发者。治疗组的术后肠蠕动恢复时间（2.15±0.69）d和住院时间（5.89±1.12）d；而对照组术后肠蠕动恢复时间（3.85±1.06）d和住院时间（10.02±1.26）d，两组差异均有统计学意义（P＜0.01）。结论：正规维持疗法能有效地提高胃十二指肠溃疡穿孔合并幽门狭窄术后对溃疡的治愈率，降低其复发率。[关键词]正规维持疗法；胃十二指肠溃疡穿孔；幽门狭窄；术后复发；奥美拉唑[]R573.1[文献标识码]B[]1673-7210（2011）07（b）-212-03PostoperativeclinicalobservationofregularmaintenancetherapyinpreventingtherecurrenceofpepticulcerperforationZHANHong激ng,CHENXin,GUXiaoguang,WANGZhitaoEasternPartoftheCityHospitalDongguanCity,Dongguan523007,China[Abstract]Objective:Tostudythetreatmentofpepticulcerwithfourdrugsongastriculcerofperforationaftermergerpyloricstenosisforregularmaintenancetreatment,observedtheclinicaleffectsinpreventingulcerrecurrence.Methods:72patientsdiagnosedasgastriculcerperforationofmergerpyloricstenosiswererandomlydividedintotwogroups:treatmentgroupwith36patientswhohavedoneulcerperforationexcisionwithfocaldiamond,relevantpyloriangioplastydrugmaintenancetherapywasappliedafteroperation(armourcyanogenmetersmetforminortorrepaclobutrazol,pullbenzodiazepines).Afterrecoveryofgastrointestinalfunction,insteadofregularmaintenancetreatment,patientstakeogilvypullthiazole(20～400)mg/dbeforebedtimeforsixmonths.Atthemeantime,patientstakeDEdebbi(folicacidbismuthpotassium)240mg2aday,destroydropsspirit400mg2aday,amoxicillin500mg2adayfor4weeks.36patientsofthecontrolgroupweregivenpostoperativedrugmaintenancetherapy,andrelevantclinicalobservationofthetwogroupswasconducted.Results:36patientsofthetreatmentgrouphavefullyrecoveredwithoutbelch,antiacid,abdominaldistension,vomitingorallmotality.Conventional:checkwithgastroscopehalfayearlatershowsthehealingofulcer,pyloricunobstructed,andnoulcersymptomsrelapseswasfoundinthefollow-upperiod.Postoperativeperistalsisrecoverytimeofthetreatmentgroupisaround2.15daysplusorminus0.69days,andthelengthoftimeinhospitalisaround5.89daysplusorminus1.12days;whilethatofthecontrolgroupisaround3.85daysplusorminus1.06daysand10.02daysplusorminus1.26daysrespectively.Thedifferenceofthetwogroupsisofstatisticalsignificance(P＜0.01).ConclusionRegularmaintenancetherapycaneffectivelyimprovethecurerateandreduceitsulcerrecurrencerateofstomachduodenalulcerperforationmergerpyloricstenosissurgery.[Keywords]Regularmaintenancetherapy;Gastriculcerperforation;Pyloricstenosis;Postoperativerecurrence;Ogilvypullthiazole本文为全文原貌未安装PDF浏览器用户请先下载安装原版全文胃十二指肠溃疡（消化性溃疡）在临床上属于一种常见病、慢性病，我国是该病的高发地区，是由于多种因素引起的胃十二指肠黏膜层和肌层的缺损。尽管有许多文献报道各种联...