肠道菌群紊乱和自闭症PatholBiol(Paris).2015Feb;63(1):35-42.doi:10.1016/j.patbio.2014.10.003.Epub2014Nov2.The"psychomicrobiotic":Targetingmicrobiotainmajorpsychiatricdisorders:Asystematicreview.FondG1,BoukouaciW2,ChevalierG3,RegnaultA4,EberlG3,HamdaniN5,DickersonF6,MacgregorA7,BoyerL8,DargelA5,OliveiraJ2,TamouzaR2,LeboyerM5.Authorinformation1InsermU955,FondaMentalFoundation,Paris-Estuniversity,ChenevierHospital,AP-HP,GHUMondor,DHUPe-Psy,PavillonHartmann,40,rueMesly,94000Créteil,France.Electronicaddress:guillaume.fond@gmail.com.2Jean-DaussetLaboratory&Inserm,UMRS940,Saint-Louishospital,1,avenueClaude-Vellefaux,75010Paris,France.3Unitédedéveloppementdutissulymphoïde,InstitutPasteur,25,rueduDr.Roux,75724Paris,France.4Inserm,InstitutPasteur,aviesan/institutmulti-organismesimmunologie,hématologieetpneumologie(ITMOIHP),bâtimentBiopark,8,ruedelaCroixJarry1(er)étage,75013Paris,France.5InsermU955,FondaMentalFoundation,Paris-Estuniversity,ChenevierHospital,AP-HP,GHUMondor,DHUPe-Psy,PavillonHartmann,40,rueMesly,94000Créteil,France.6StanleyResearchProgram,SheppardPrattHealthSystem,6501N,CharlesStreet,MD21204Baltimore,UnitedStates.7InsermU1061,academicadultpsychiatrydepartment,Montpellier1university,LaColombièrehospital,MontpellierCHRU,191,avenuedudoyenGaston-Giraud,34295Montpelliercedex,France.8EA3279-Self-perceivedHealthAssessmentResearchUnit,SchoolofMedicine,LaTimoneUniversity,27,boulevardJean-Moulin,13385Marseillecedex05,France.AbstractThegutmicrobiotaisincreasinglyconsideredasasymbioticpartnerinthemaintenanceofgoodhealth.Metagenomicapproachescouldhelptodiscoverhowthecomplexgutmicrobialecosystemparticipatesinthecontrolofthehost'sbraindevelopmentandfunction,andcouldberelevantforfuturetherapeuticdevelopments,suchasprobiotics,prebioticsandnutritionalapproachesforpsychiatricdisorders.Previousreviewsfocusedontheeffectsofmicrobiotaonthecentralnervoussystemininvitroandanimalstudies.Theaimofthepresentreviewistosynthetizethecurrentdataontheassociationbetweenmicrobiotadysbiosisandonsetand/ormaintenanceofmajorpsychiatricdisorders,andtoexplorepotentialtherapeuticopportunitiestargetingmicrobiotadysbiosisinpsychiatricpatients.BehavBrainRes.2015Feb1;278:542-8.doi:10.1016/j.bbr.2014.10.050.Epub2014Nov6.Intracerebroventricularinjectionofpropionicacid,anentericmetaboliteimplicatedinautism,inducessocialabnormalitiesthatdonotdifferbetweenseizure-prone(FAST)andseizure-resistant(SLOW)rats.ShultzSR1,AzizNA2,YangL3,SunM2,MacFabeDF4,O'BrienTJ2.Authorinformation1MelbourneBrainCentre,DepartmentofMedicine,TheRoyalMelbourneHospital,TheUniversityofMelbourne,Parkville,VIC,Australia.Electronicaddress:sshultz@unimelb.edu.au.2MelbourneBrainCentre,DepartmentofMedicine,TheRoyalMelbourneHospital,TheUniversityofMelbourne,Parkville,VIC,Australia.3MelbourneBrainCentre,DepartmentofMedicine,TheRoyalMelbourneHospital,TheUniversityofMelbourne,Parkville,VIC,Australia;DepartmentofHistologyandEmbryology,KunmingMedicalUniversity,Kunming,Yunnan,China.4TheKileePatchell-EvansAutismResearchGroup,DepartmentofPsychologyandPsychiatry,UniversityofWesternOntario,London,ON,Canada.AbstractAutismisacomplexneurodevelopmentaldisorderthatischaracterizedbysocialabnormalities.Genetic,dietaryandgut-relatedfactorsareimplicatedinautism,howeverthecausalpropertiesofthesefactorsandhowtheymayinteractareunclear.Propioni...