中国组织工程研究第16卷第11期2012–03–11出版ChineseJournalofTissueEngineeringResearchMarch11,2012Vol.16,No.11创面修复“TIME”原则及其意义****★◆徐媛，刘宏伟“TIME”principlesanditsclinicalsignificanceinwoundrepairXuYuan,LiuHong-weiAbstractBACKGROUND:Whilethecellularandmolecularmechanismsofwoundhealinghavebeenunderstoodgraduallyandtheexperiencesofwoundbedmanagementhavebeenaccumulated,theimportanceofwoundbedpreparationtowoundrepairhasrecentlyattractedmoreattention.OBJECTIVE:Tofullyanalyzethemechanismsofwoundhealing,variousinfluencefactorsandtheireffectsinthisprogress.METHODS:AnonlinesearchofCNKIandPubMeddatabaseswasperformedforarticlespublishedbetween1994and2011,usingkeywordsof“TIMEprinciples,woundbedpreparation,woundhealing”inChineseandEnglish,respectively.Theclinicalapplicationprinciplesandoutcomesofwoundhealingwereanalyzed.RESULTSANDCONCLUSION:Atotalof498paperswerecollected,and24ofthemwereincludedaccordingtoinclusivecriteria.TIMEistheinitialsoffourprinciplesinwoundbedmanagement.Tmeanstoremovethenecrotictissue.Imeanstocontroltheinfectionandtoreducetheinflammation.Mmeanstokeepthewoundmoistureundernormalconditionforthegranulationtissuegrowthandre-epithelialization.Emeanstoremovenonmigratingepidermisattheedgeofwound.Asavaluableguidancetoolforwoundmanagement,theTIMEconcepthasbeenappliedtoclinicalpractice,andhasbeenwidelyappreciatedbyclinicans.XuY,LiuHW.“TIME”principlesanditsclinicalsignificanceinwoundrepair.ZhongguoZuzhiGongchengYanjiu.2012;16(11):2059-2062.[http://www.crter.cnhttp://en.zglckf.com]摘要背景：随着人们对创面愈合机制研究的深入和创面处理经验的积累，创床的准备对于创面修复的重要性越来越引起人们的高度重视。目的：全面了解创面愈合的机制，明确影响创面愈合的各种影响因素及其作用。方法：电子检索中国期刊全文数据库(1994/2011)和PubMed数据库(1994/2011)，检索词分别为“TIME原则，创面准备，创面愈合”和“TIMEprinciples,woundbedpreparation,woundhealing”，语言分别设定为中文和英文，分析创面愈合临床应用原则及效果的研究进展。结果与结论：共检索到文献498篇，阅读标题和摘要后，按纳入标准，共纳入22篇。TIME为创面处理过程中创床准备4项原则性的方法的首个英文字母的缩写，即：T指清除创面坏死组织(tissue)；I指控制炎症、减轻感染(infection/inflammation)；M指保持创面正常的湿度为肉芽组织生长和创面上皮化创造条件(moisture)；E指去除创缘迁移受损的表皮(edgeofwound,nonmigrating)。目前TIME原则作为一个有价值的创面处理指导工具受到临床医生的好评，并应用于临床实践。关键词：创伤愈合；溃疡；清创；慢性创面；创面分析doi:10.3969/j.issn.1673-8225.2012.11.037徐媛，刘宏伟．创面修复“TIME”原则及其意义[J].中国组织工程研究，2012，16(11):2059-2062.[http://www.crter.orghttp://cn.zglckf.com]理过程中创床准备四项原则方法的首个英文字DepartmentofPlasticSurgery,theFirstAffiliatedHospitalofJinanUniversity,KeyLaboratoryforRegenerativeMedicine,MinistryofEducation,Guangzhou510630,GuangdongProvince,ChinaXuYuan★,Master,Physician,DepartmentofPlasticSurgery,theFirstAffiliatedHospitalofJinanUniversity,KeyLaboratoryforRegenerativeMedicine,MinistryofEducation,Guangzhou510630,GuangdongProvince,Chinayuan_xu@foxmail.comCorrespondingauthor:LiuHong-wei,Associatechiefphysician,Doctoralsupervisor,DepartmentofPlasticSurgery,theFirstAffiliatedHospitalofJinanUniversity,KeyLaboratoryforRegenerativeMedicine,MinistryofEducation,Guangzhou510630,GuangdongProvince,Chinaliuhongwei0521@hotmail.comSupportedby:the0引言创面修复是指由于各种因素造成皮肤组...