腹股沟皮瓣游离移植联合负压封闭引流修复胫前大面积软组织缺损刘伟1,肖军1,郑佐勇1,肖艳1,李晓菲1,区广鹏1,黄瑞良1,艾合买提江•玉素甫21广东医学院附属高明医院骨一科,广东省佛山市528500;2新疆医科大学第一附属医院骨科中心,新疆维吾尔自治区乌鲁木齐市835200VacuumsealingdrainagecombinedwithgroinflapgraftrepairssofttissuedefectsintheanteriortibiaLiuWei1,XiaoJun1,ZhengZuo-yong1,XiaoYan1,LiXiao-fei1,OuGuang-peng1,HuangRui-liang1,Ahmatjiang•Yusufu21FirstDepartmentofOrthopedics,GaomingHospitalAffiliatedtoGuangdongMedicalCollege,Foshan528500,GuangdongProvince,China;2OrthopedicCenter,theFirstAffiliatedHospitalofXinjiangMedicalUniversity,Urumqi835200,XinjiangUygurAutonomousRegion,China摘要背景:合并严重软组织并骨缺损的下肢开放性骨折,伤后胫前皮肤软组织坏死缺损,骨质、钢板外露等在临床上经常发生,关键在于坚强的骨折固定以及合理应用血供可靠的皮瓣封闭创面。目的:探讨负压封闭引流联合腹股沟游离皮瓣修复胫前大面积软组织缺损的效果。方法:纳入胫前大面积软组织缺损患者24例,根据修复方案分为2组,各12例。负压封闭引流组软组织缺损范围10cm×15cm-15cm×20cm。经清创后,外固定支架固定骨折,使用负压封闭引流敷料覆盖创面,三通管接生理盐水随时冲洗血块,7-10d去除负压封闭引流负压,根据肉芽组织生长情况给予二期缝合,行旋髂浅动脉的髂腹股沟游离皮瓣与膝下内侧动静脉吻合移植修复。非负压封闭引流组创面大小10cm×15cm-30cm×20cm,受伤至入院时间1-24h。普通清创换药,二期固定或者皮瓣转移。结果与结论:修复前住院时间及皮瓣面积比较,负压封闭引流组显著优于非负压封闭引流组(P<0.05);2组修复术后住院时间、总住院时间差异均无显著性意义(P>0.05)。负压封闭引流组修复治疗后创面感染率为0,非负压封闭引流组治疗8-14d后创面感染率为75%。2组创面及供区切口均Ⅰ期愈合,植皮顺利成活。2组患者均获随访,随访时间6-36个月,随访过程中非负压封闭引流组骨折愈合时间显著长于负压封闭引流组。2组皮瓣与周围皮肤色泽、质地相似,皮瓣受力处无血管危象的发生,无破溃,无臃肿。提示负压封闭引流联合腹股沟游离皮瓣修复对及时控制创伤后大面积软组织缺损感染,改善创面血运,缩短术前准备时间,及早闭合创面,促进创面及骨折愈合有显著作用,皮瓣质地柔韧,外观良好,活动功能良好,可明显缩短疗程,最大限度恢复患肢功能中国组织工程研究杂志出版内容重点:肾移植;肝移植;移植;心脏移植;组织移植;皮肤移植;皮瓣移植;血管移植;器官移植;组织工程全文链接:关键词:实验动物;组织构建;负压封闭引流;腹股沟皮瓣;游离移植;大面积软组织缺损;Abstract:BACKGROUND:Openfractureoflowerlimbwithseveresofttissueandbonedefectsalsoaccompaniesanteriortibialsofttissuedefectsandexposureofsclerotinandsteelplate,whichcanbecruciallytreatedwithstrongfixationanduseofskinflaptoblockthewound.OBJECTIVE:Toexploretheclinicalefficacyofalargeareaofsofttissuedefectsintheanteriortibiausingvacuumsealingdrainagecombinedwithgroinfreeflap.METHODS:Atotalof24patientswithalargeareaofsofttissuedefectsintheanteriortibiawereincludedinthisstudyandthendividedintotwogroups,with12casesineachgroup.Invacuumsealingdrainagegroup,thescopeofsofttissuedefectswasrangedfrom10cm×15cmto15cm×20cm.Afterthedebridement,thefracturewasfixedwithexternalfixationscaffoldandthewoundwascoveredwiththevacuumsealingdrainagedressing.ThebloodclotwasrinsedwithnormalsalineviaT-tube,and7-10dayslaterthevacuumsealingdrainagewasgiven.Accordingtothegrowthofgranulationtissue,thewoundwassecondarilysutured,followedbygroinfreeskinflapofsuperficialiliaccircumflexarterywithmedialkneearteriovenousanastomosistransplantation.Inthenon-vacuumsealingdrainagegroup,thewoundsizewasranged...