中国组织工程研究与临床康复第15卷第8期2011–02–19出版February19,2011Vol.15,No.8JournalofClinicalRehabilitativeTissueEngineeringResearch周围神经损伤修复及功能恢复评价☆吕荣PeripheralnerveinjuryrepairandfunctionalrecoveryLüRongAbstractOBJECTIVE:Toevaluatetheproperties,applicationandevaluationmethodoffunctionalrecoveryintherepairofperipheralnervedefectsusingvariousbiologicalartificialmaterials,andtosearchasuitablealternativetoperipheralnerves.METHODS:Using“nerveconduit,peripheralnerverepair,biomaterials,Schwanncells”inChineseaskeywords,acomputerretrievalforarticlesfromJanuary2004toNovember2010wasperformed.Literaturesabouttissueengineeringnerveandbiomaterialswereincluded;repeatstudyorMetaanalysisarticleswereexcluded.Atotalof59papersmainlyfocusthetype,performance,andappropriateevaluationmethodoffunctionalrecoveryofbiologicalartificialmaterialsontherestorationofperipheralnerve.RESULTS:Theacellularnervematrixandthecompositebiologicalengineeredmaterialsbasedonsyntheticdegradablematerialsasthemainbody,canbeusedasidealscaffoldmaterialsforperipheralnervetissueengineering.Acellularnervescaffoldssolvelimitedsourceofautologousnerve,graftrejectionandotherproblems,itstoughnessandplasticityareclosetoautologousnerve,itsmicro-environmentismoreconducivetoperipheralnerveregeneration.Syntheticbiodegradablematerialshavebiodegradability,plasticity,permeabilityandotheradvantages,andthecommercializedproductshaveemerged.Ifsuchmaterialswereusedtostructurethecomplexmaterials,itislikelypossibletoobtaintissueengineerednervegraftwithgoodperformance.Functionalrecoveryafterperipheralnerverepairismainlyassessedbygeneralandmorphology,histologicalobservations,neuromuscularfunctionassessment,aswellasmolecularbiologytechniques.Theapplicationofvariousevaluationmethodsisconducivetoscreenouttherepairmaterialsandconstructionprogramsofperipheralnerveinjury.CONCLUSION:Thebiologicalartificialmaterialsintherestorationofperipheralnerveinjuryarerapidlydeveloping,butstillneedascaffoldofautologousnervegraft.Acellularnervematrixandcompositematerialsofsyntheticbiodegradablescaffoldscanbeusedasgoodscaffoldforperipheralnerve,butstillneedthejointconstructionwithseedcellsandneurotrophicfactors,inordertoachievegoodresultsinpromotingregeneration.Atpresent,theeffectofrepairingperipheralnerveinjuryischieflyevaluatedbytheassessmentofneuromuscularfunctionrecovery,itisanurgentneedtofindoptimalrepairmaterialsandoptimalconstructionschemetomeettissueengineeringneuraltransplantationandfunctionalrehabilitationrequirements,thusachievingrepairofmorphology,structureandfunctionalreconstructionfollowingperipheralnerveinjury.LüR.Peripheralnerveinjuryrepairandfunctionalrecovery.ZhongguoZuzhiGongchengYanjiuyuLinchuangKangfu.2011;15(8:1454-1458.[http://www.crter.cnhttp://en.zglckf.com]InstituteofPhysicalEducation,SoochowUniversity,Suzhou215021,JiangsuProvince,ChinaLüRong,Doctor,Lecturer,InstituteofPhysicalEducation,☆SoochowUniversity,Suzhou215021,JiangsuProvince,Chinalvrong@njnu.edu.cnReceived:2010-11-02Accepted:2011-01-12摘要目的：评价修复周围神经缺损的各种生物型人工材料的性能、“应用以及功能恢复评定方法，寻找适宜的周围神经替代物。方法：以神经导管，周围神经损”伤修复，生物材料，许旺细胞为关键词，采用计算机检索2004-01/2010-11相关文章。纳入与生物材料以及组织工程神经相关的文章；排除重复研究或Meta分析类文章。以28篇文献为主，重点讨论周围神经修...