红细胞分布宽度在慢性阻塞性肺疾病中的诊断价值［摘要］目的探讨红细胞分布宽度（RDW）对慢性阻塞性肺疾病（COPD）的诊断价值，为COPD的早期诊断发掘新的标志物。方法采集2015年11〜12月成都中医药大学附属医院COPD患者（204例）、肺恶性肿瘤患者（96例）及健康体检者（71例）的静脉血2mL，检测三组的RDW值，one-wayANOVA法比较三组间RDW值变化。绘制RDW诊断COPD的受试者工作曲线（ROC曲线），计算灵敏度、特异度和约登指数，诊断界值cut-off值。结果与健康体检者比较，RDW在COPD患者及肺恶性肿瘤患者中均显著升高（P［关键词］红细胞分布宽度；慢性阻塞性肺疾病；诊断标志物；诊断价值［中图分类号］R563.9［文献标识码］A［文章编号］1673-7210（2016）04（a）-0123-04DiagnosticvalueofredbloodcelldistributionwidthonchronicobstructivepulmonarydiseaseHUQiongyingZHANGShuangZENGYuZHANGChaomingDepartmentofLaboratoryMedicine,TeachingHospitalofChengduUniversityofTraditionalChineseMedicine，SichuanProvince,Chengdu610072，China[Abstract]ObjectiveTodiscussthediagnosticvalueofredbloodcelldistributionwidth(RDW)onchronicobstructivepulmonarydisease(COPD)，andexploreanewdiagnosticmarkerforCOPD.MethodsFromNovembertoDecember2015，inTeachingHospitalofChengduUniversityofTraditionalChineseMedicine，venousblood2mLofCOPDpatients(204cases)，pulmonarymalignanttumorpatients(96cases)andhealthpeople(71cases)werecollected，theRDWlevelsweredetectedandcomparedbyone-wayANOVA.Thereceiveroperatorcharacteristiccurve(ROC)wasdrew，sensitivity,specificityandYouderfsindex(YI)，cut-offvaluewerecalculated.ResultsRDWlevelsrosesignificantlyinCOPDpatientsandpulmonarymalignanttumorpatientscomparedwithhealthgroup(P综上所述，RDW预测COPD具有较高的诊断价值，可作为COPD早期诊断及鉴别诊断的潜在标志。[参考文献][1]Ersoy0，GultekinB，OzkanM，etal.Effectofleftventricularassistdevicesonredbloodcelldistributionwidth[J].ExpClinTransplant,2015，13(Suppl3)：137-139.[2]BujakK，WasilewskiJ,OsadnikT,etal.Theprognosticroleofredbloodcelldistributionwidthincoronaryarterydisease：areviewofthepathophysiology[J].DisMarkers，2015，2015：824624.[3]NadaAM.Redcelldistributionwidthintype2diabeticpatients[J].DiabetesMetabSyndrObes,2015,8：525-533.[4]IpekS，CekicC，AlperE，etal.Canredcelldistributionwidthbeamarkerofdiseaseactivityinulcerativecolitis?[J].IntJClinExpMed，2015，8(8):13848-13853.[5]WangD，YangJ，ZhangJ，etal.Redcelldistributionwidthpredictsdeathsinpatientswithacutepancreatitis[J].JResMedSci，2015，20(5):424-428.[6]Peri??laV，ZibarL,Sini-PetrieviJ，etal.RedbloodcelldistributionwidthasasimplenegativeprognosticfactorinpatientswithdiffuselargeB-celllymphoma：aretrospectivestudy[J].CroatMedJ，2015,56(4)：334-343.[7]PengYF，ZhangQ，CaoL,etal.Redbloodcelldistributionwidth：apotentialmakerestimatingdiseaseactivityofankylosingspondylitis[J].IntJClinExpMed,2014,7(12)：5289-5295.[8]EwedaI，HamadaG.ConcordancebetweenDopplerandpulsed-waveDopplertissueimaginginestimationofthedegreeofleftventriculardysfunctionandcorrelatingittothedegreeofchronicobstructivepulmonarydisease[J].JSaudiHeartAssoc，2016，28(1)：15-21.[9]HwangYI,LeeSH,YooJH，etal.Historyofpneumoniaisastrongriskfactorforchronicobstructivepulmonarydisease(COPD)exacerbationinSouthKorea：theEpidemiologicreviewandprospectiveobservationofCOPDandhealthinKorea(EPOCH)[J].JThoracDis,2015,7(12)：2203-2213.[10]CameronSJ，LewisKE，HuwsSA，etal.Metagenomicsequencingofthechronicobstructivepulmonarydiseaseupperbronchialtractmicrobiomerevealsfunctionalchan...