彩色多普勒超声动态观察对围生期脑损伤的应用研究彩色多普勒超声动态观察对围生期脑损伤的应用研究摘要:目的:探讨彩色多普勒超声动态观察对不同时期围生儿脑损伤的应用价值。方法:应用彩色多普勒超声检查动态观察窒息足月儿缺氧缺血性脑病(HIE)78例,早产儿脑白质软化(PVL)65例,极低体重儿(VLBWI)脑室内出血(HIV)35例,正常对照组100例的脑血流动力参数变化及二维超声改变。结果:头颅彩色多普勒超声检测HIE组、PVL组及VLBWI组,ACA、MCA、PCA的Vs、Vd及Vm均降低,与对照组比较,有统计学意义(P〈0.05)。HIE组PI、RI明显增高,与对照组比较,有统计学意义(P<0.05)o足月儿缺氧缺血性脑损伤二维超声表现为脑实质回声弥漫性增强,脑结构模糊伴侧脑室裂隙变窄或消失。早产儿白质损伤及脑室内出血程度与胎龄、体重有关。结论:彩色多普勒超声动态监测不同时期围生儿脑损伤的脑血流动力学改变,可获取早期脑损伤时的重要参数,对预测脑损伤程度,评估预后有较好临床意义。关键词:彩色多普勒围生期脑损伤头颅超声ThecoloredDopplersupersonicdynamicobservationappliedresearchdamagestotheperinatalstagebrainLiangJianAbstractObjective:DiscussioncoloredDopplersupersonicdynamicobservationencirclestothedifferenttimelivestheapplicationvaluewhichthebraindamages.Methods:AppliesthecoloredDopplersupersonicinspectiondynamicobservationtosuffocatethefull—termoxygendeficitanemicbrain订Iness(HIE)78example,theprematureinfantbrainwhitemattersoftensthe(PVL)65example,extremelylowbodyweightson(VLBWI)ventridesofthebraininternalhemorrhage(HIV)35examples,normalcontrolgroup100examplebrainbloodstreamdynamicparameterchangesandtwo-dimensionalsupersonicchange・Results:HeadcoloredDopplersupersonicexaminestheHIEgroup,thePVLgroupandtheVLBWIgroup,ACA,MCA,PCAVs,VdandVmreduces,compareswiththecontrolgroup,hasstatisticssignificance(P<0.05).HIEgroupPI,theRIobviousmarkup,compareswiththecontrolgroup,hasstatisticssignificance(P<0.05).Thefull-termoxygendeficitanemicbraindamagetwo-dimensionalsupersonicperformaneestrengthensforthebrainessenceechodiffused,thebrainstructurefuzzypartnerventriculilateralsenciphalicrevassestrictsorvanishing.Theprematureinfantwhitematterdamageandtheventriclesofthebraininternalhemorrhagedegreeandtheembryoage,thebodyweightconcern.Conclusion:ThecoloredDopplersupersonicdynamicmonitordifferenttimeencircleslivesthebrainbloodstreamdynamicschangewhichthebraindamages,maygaintheearlybraindamageswhentheimportantparameter,toforecastthebrainextentofdamage,appraisedtheprognosishasthegoodclinicalsignificanee.Keywords:ColoredDopplerPerinatalstageBraindamageHeadsupersonic【中图分类号】R445【文献标识码】A【文章编号】1008-1879(2010)12-0038-02随着围生医学、NICU的建立,窒息新生儿和早产儿的存活率不断增加,但如何提高其生存质量,如何对脑损伤早期诊断、早期治疗也是围生期医学的研究热点,本研究应用彩色多普勒超声动态观察不同时期围纶儿脑损伤的脑血流动力学及声像改变,探讨其对围纶期脑损伤的应用价值。1对象和方法1.1研究对象。2007年1刀至2008年12月住北流市人民医院新生儿科有窒息史新生儿进行头颅超声检查;其中窒息足月儿缺氧缺血性脑病(HIE)78例,早产儿脑白质软化(PVL)65例,极低体重儿(VLBWI)脑室内出血(IIIV)35例,正常对照组100例进行颅脑彩色多普勒超声检查。HIE组78例,胎龄39±1.7周,男38例,女30例,Apgar评分0-5分,无合并感染及先天性心脏病。PVL组65例。胎龄33±3.2周,男48例,女17例。其中出生重度窒息20例,双胎6例,新半儿吸入性肺炎21例,高危围产期异常病史28例,其中孕高征18例,母体梅毒1例,重度贫血4例,羊水3度浑浊5例。出生Apgar评分5-10分。VLBWI一HIV组35例,男婴27例,女婴8例。胎龄28〜36周,体重802~1500go出生Apgar评分3-10分,...