【摘要】目的：观察局部晚期鼻咽癌诱导化疗局部晚期鼻咽癌TP方案诱导化疗及同期放化疗初步观察及不同化疗方案的依从性及不良反应。方法：将60例局部晚期鼻咽癌患者按照随机数字表法分为A、B、C三组，A组TP诱导化疗+同期顺钳放化疗，B组顺钳同期放化疗，C组TP同期放化疗。放疗为调强放疗，GTVnx68〜72Gy,GTVnd65〜70Gy。观察三组治疗依从性及不良反应情况。结果：三组完成化疗数比例分别为80.0%>95.0%、90.0%,放疗全部足量完成，依从性均好，最常见反应为胃肠道反应、口咽黏膜炎、骨髓抑制、皮肤损伤，三组比较差异均无统计学意义(P>0.05)o但同时中重度不良反应发生率A组最高，B组最低，差异有统计学意义(P【关键词】局部晚期鼻咽癌；同期放化疗；诱导化疗；不良反应PreliminaryResearchofTP-basedInductionChemotherapyandConcurrentChemotherapyintheTreatmentofLocallyAdvancedNPC/LIJin-wei,XIAOHai,WANGRong,etal.//MedicalInnovationofChina,2016,13(27)：010-013【Abstract】Objective：Toobservetheadherenceandadversereactionsofinductionchemotherapyanddifferentconcurrentchemotherapyregimens---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---forlocallyadvancednasopharyngealcarcinoma(NPC)・Method：Atotalof60patientswithlocallyadvancedNPCwererandomlydividedintoA,B,Cgroups,20casesineachgroup.GroupAwasgivenTP-basedinductionchemotherapy,followedbyconcurrentchemoradiotherapywithcisplatin；GroupBwasgivenCisplatin-basedconcurrentchemoradiotherapy.GroupCwasgivenTP-basedconcurrentradiochemotherapy.RadiotherapywasusedbyIMRT,GTVnx68-72Gy,GTVnd65-70Gy.Thetreatmentcomplianceandincidenceofadversereactionsofthreegroupswereobserved.Result：GroupA,BandCcompletedtheexpectednumberofchemotherapyrateswere80.0%,95.0%,90.0%.Radiotherapywerecompletedatsufficientamount,compliancewasgood,themostcommonweregastrointestinal,oropharyngealmucositis,myelosuppression,skindamage.Insevereinjuriesdifferenceswerenostatisticaldifference(P>0.05).Butalladversereactionsrateswerestatisticallydifferent,groupAwasthehighest,groupBwasthelowest,therewasstatisticalsignificance(P---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---