miRfi7j92启动子区基因多态性与子宫内膜癌易感性及预后的相关性*†接智慧i,周岩，吴慧丽,郑莉莉，李萍，高翔(山东第一医科大学第二附属医院妇产科，泰安271000)II摘要银目的：探讨miR517j92基因启动子区基因多态性与子宫内膜癌(EC)易感性及预后的关系。方法:应用聚合酶链反应邺连接酶反应检测398例EC患者与420例健康人群miR?17B92基因簇启动子区rsl813389AG,rs9515692CT两个单核昔酸多态性(SNP)位点的基因型，并分析两个位点SNP与EC发病和预后的相关性。结果：与携带rs!813389AA基因型者相比，GG基因型显著降低EC的发病风险(OR=0.49,95%CI=0.32~0.78,PR.002),与A等位基因携带者相比,G等位基因显著降低EC的发病风险(OR=0.75,95%CI=0.62~0.91,P=0.005);与携带rs9515692CC基因型者相比,TT基因型可显著降低EC发病风险(OR=0.53,95%CT=0.34、0.82,P=0.004),与C等位基因的携带者相比，T等位基因可降低EC的发病风险(OR=0.77,95%CT=0.63~0.94,P=0.010),预后分析显示rsl813389AG或GG基因型是EC患者预后的独立影响因素(HR=0.49,95%CI=0.36~0.82,P=0.007;HR=0.29,95%CI=0.16~0.83,P=0.017)。结论:miR|17j92基因簇启动子区rsl813389AG、rs9515692CT多态性可能成为中国华北地区女性EC发病和预后判断的分子标志物。犊关键词％miR517592;多态性；子宫内膜癌；易感性;预后中图分类号:R737.33文献标志码：A文章编号:1004-7379(2021)11-0805-05DOI:10.13283/j.cnki.xdfckjz.2021.11.001AssociationbetweenpolymorphismsinthepromoterregionofthemiR317粉2clusterandendometrialcancer.JieZhihui,ZhouYan,WuHuili,etal.DepartmentofObstetricsandGynaeSoology,TheSecondAffiliatedHospitalofShandongFirstMedicalUniversity,Taian271000SAbstractSEObjective:ToinvestigatetherelationshipbetweenthepolymorphismofmiRn7|92andthesusceptibilityandprognosisofendometrialcancer(EC)innorthernChifnesewomen.Methods:Throughcaselcontrolstudy,polymerasechainreactionandligasedetecttionreaction(PCR§LDR)wasusedtodetectthepolymorphismofrs!813389AGandrs9515692CTinmiRS17592promoterregionof398casesofECand420healthycontrolsubljects,andtoanalyzethecorrelationbetweenthetwoSNPSandtheincidenceandprognosisofEC.Results:Comparedwithrs!813389AAgenotypecarriers,GGgenotypesignificantlyreducedtheriskofEC(OR=0.49,95%CI=0.32~0.78,P=0.002).ComparedwithcarriersofalleleA,theGallelesignificantlyreducedtheriskofEC(OR=0.75,95%CI=0.62~0.91,P=0.005).Comparedwithrs9515692CCgenotypecarriers,TTgenotypesignificantlyreducedtheriskofEC(OR=0.53,95%CI=0.34~0.82,P=0.004).ComparedwithcarriersoftheCalllele,theTalleledecreasedtheriskofdevelopingEC(OR=0.77,95%C1=O.63~0.94,P=0.010).Prognosticanalysisshowedthatrsl813389AGorGGgenot)rpeswereindependentfac邺**山东省医药卫生科技发展计划项目(No:202005011317);泰安市科技发展计划项日(No:2018NS0205)†通信作者Email:zhihuijie365@126.com---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---torsinfluencingtheprognosisofECpatients(HR=0.49,95%CI=0.36〜0.82,P=0.007:HR=0.29,95%CI=0.1683,P=0.017).Conclusion:Rsl813389AGandrs9515692CTpolymorphismsinthepromoterregionofthem辎17*92clustermaybeamolecularmarkerforthediagnosisofECmorbidityandprognosisinnorthernChinesewomen.括KeywordsijmiRjl7船2;PolymorphismEndometrialcancel：Susceptibility;Prognosis子宫内膜癌（endometrialcancer,EC）是全球范围内第二常见女性生殖系统恶性肿瘤，也是导致妇科癌症相关死亡的第三常见原因，其发病呈年轻化趋势[1].口谪EC治疗I•.存在较爹限制.思者雁以达到治愈效果耳探索EC的发病机制、寻找早诊早治的潜在靶点，对于改善EC患者的预后极其重要，近年来,miRNA与肿瘤的关系是肿瘤学研究的热点之一，其中最具有代表性的是miR517!92基因簇，其由6种成熟的miRNA组成，研究己发现miRS17®2...