铂类新辅助化疗联合同步放化疗治疗中晚期宫颈鳞癌的临床疗效分析基金项目:海南省卫计卫科研项目(１４A２１０２２３)作者简介:张颖(１９６８－),女,本科,副主任护士,研究方向:肿瘤护理,EＧmail:１３８０７５７０５５５＠１６３．.????????????????????????????????????????????????????????????????????????????????????????????本文引用:张颖,莫安薇．铂类新辅助化疗联合同步放化疗治疗中晚期宫颈鳞癌的临床疗效分析[J]．医科大学学报,２０１９,４２(４):４８４Ｇ４８８．doi:１０．３９６９/j．issn．１００９Ｇ５５５１．２０１９．０４．０１２铂类新辅助化疗联合同步放化疗治疗中晚期宫颈鳞癌的临床疗效分析张颖１,莫安薇２(海南省人民医院１护理部,２肿瘤内科,海南海口５７０３１１)摘要:目的研究铂类新辅助化疗联合同步放化疗对中晚期宫颈鳞癌的治疗效果.方法选取２０１４年１月－２０１７年１２月海南省人民医院肿瘤内科收治的符合纳入标准的中晚期宫颈鳞癌患者１１２例,分为常规组和对照组,常规组采用同步放化疗的方案治疗,对照组采用铂类新辅助化疗联合同步放化疗的方案治疗,观察２组患者的总有效率、病灶缩小率、肿瘤最大直径、分期变化和复发率的变化,运用重复测量方差分析观察２组患者肿瘤最大直径在治疗后３个月、１年、２年、３年的变化情况.随访３年,绘制KaplanＧMeier生存曲线分析２组患者的预后差异.结果２组患者治疗后疗效评价、总有效率、病灶缩小率、肿瘤最大直径、分期变化较前明显改善(P均＜０．０５).在治疗后３个月、１年、２年、３年,对照组在治疗后各时间点肿瘤最大直径显著低于常规组(P均＜０．０５);KaplanＧMeier生存曲线结果显示,对照组的治疗效果优于常规组(P均＜０．０５);对照组治疗后并发症发生率高于常规组(P均＜０．０５).结论铂类新辅助化疗联合同步放化疗对中晚期宫颈鳞癌的治疗效果优于同步放化疗,但其治疗后并发症发生率高于同步放化疗.铂类新辅助化疗联合同步放化疗对宫颈鳞癌治疗的综合效果仍待进一步研究.关键词:铂类;新辅助化疗;同步放化疗;宫颈鳞癌:R７３７．３３:A:１００９Ｇ５５５１(２０１９)０４Ｇ０４８４Ｇ０５doi:１０．３９６９/j．issn．１００９Ｇ５５５１．２０１９．０４．０１２ClinicalvalueofplatinumneoadjuvantchemotherapybinedwithsimultaneousradiotherapyandchemotherapyinthetreatmentofcervicalsquamouscellcarcinomainthemiddleandlatestagesZHANGYing１,MOAnwei２(１DepartmentofUrsing,２DepartmentofOncology,HainanProvincialPeople′sHospital,HaikouHainan５７０３１１,China)Abstract:ObjectiveToexploretheclinicalvalueofplatinumneoadjuvantchemotherapybinedwithsimultaneousradiotherapyandchemotherapyinthetreatmentofcervicalsquamouscellcarcinomainthemiddleandlatestages．Methods１１２patientswithadvancedcervicalsquamouscellcarcinomawhomettheinclusioncriteriaintheDepartmentofOncology,HainanProvincialPeople′sHospitalfromJanuary２０１４toDecember２０１７wereselectedanddividedintotheroutinegroupandthecontrolgroup．Theregular第４２卷第４期医科大学学报Vol．４２No．４２０１９年４月JournalofXinjiangMedicalUniversityApr．２０１９groupwastreatedwithconcurrentradiotherapyandchemotherapyandthecontrolgroupwastreatedwithplatinumneoadjuvantchemotherapybinedwithsimultaneousradiotherapyandchemotherapy．Thetotaleffectiverate,therateoflesion,themaximumdiameterofthetumor,thechangeofstageandrecurＧrencerateofthetwogroupsbeforeandaftertreatmentwereobserved．After３yearsfollowＧup,thedifferＧenceofprognosisbetweenthetwogroupswasanalyzedbyKaplanＧMeiersurvivalcurve．ResultsTheevalＧuationofcurativeeffectaftertreatmentinbothgroupsshowedthatthetotaleffectiverate,lesionreductionrate,tumormaximumdiameterandstagechangeweresignificantlyimprovedparedwiththosebeforetreatment(P＜０．０５)．At３months,１year,２years,３y...