磁敏感加权成像在豆状核大脑老化中的研宄价值王波龚霞蓉马莎张宏江陈婧张洁任丽香(通讯作者)(云南省第一人民医院昆明理工大学医学院云南昆明650032)【摘要】目的：釆用3.0T磁敏感加权成像定量测量健康成年人豆状核的相位值，探讨正常脑老化过程中豆状核的脑铁沉积与侧别、性别及年龄的相关性。方法：⑴收集年龄20〜85岁的126例年龄相匹配的男性组及女性组进行MRI常规及ESWAN扫描，经后处理在校正相位图像上分別测量左/右侧壳核、苍白球的相位值，分析相位值与侧别、性别的相关性。⑵收集年龄20〜85岁的157例健康成年人进行MRI常规及ESWAN扫描，按其年龄段分为六组。A组:20〜29岁，B组：30〜39岁，C组：40〜49岁，D组：50〜59岁，E组：60〜69岁，F组:ge;70岁。经后处理在校正相位图像上分别测量左/右侧壳核、苍白球的相位值，分析正相位值与年龄的相关性。结果：⑴男性组和女性组左/右侧壳核、苍白球的相位值无统计学差异(P》0.05);⑵健康成年人壳核、苍白球的相位值与性別无相关性(P》0.05)。⑶壳核、苍白球的相位值在各年龄段间无统计学意义(P》0.05)；与年龄无相关性(r值=-0.072、-0.049,P值均〉0.05)。结论：健康成年人豆状核的脑铁含量与侧别、性别及年龄均无相关性。【关键词】磁共振成像；脑铁沉积；性别；年龄【】R445【文献标识码】A【】2095-1752(2016)04-0083-03TheStudyofSWIEvaluateinlenticularnucleusofbrainagingWangBo,GongXia-rong,MaSha,ZhangHong-激ang,Chen激ng,Zhang激e,RenLi-xiang(Communicationauthor)TheFirstPeoplesHospitalofYunnanProvince,MedicalFacultyofKunmingUniversityofScienceandTechnology,Kunming,Yunnan,650032,China【Abstract】ObjectiveToquantitativelyanalyzetheirondepositioninlenticularnucleusinhealthypopulationanditscorrelationwiththelaterality,genderandage---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---duringbrainagingusingESWAN(enhancedgradientechoT2star-weightedangiography)with3.0Teslascanner.Methods(l)Agematched126healthyvolunteerswithagerangingfrom25to85werescannedwith3.0TMRIroutinesequencesandESWANsequences.Phasevalueweremeasuredinbothsidesofputamenandglobuspallidus,andthecorrelationsbetweenphasevalueandlaterality,genderwereanalyzed.(2)157healthysubjects(age20to85)hadbeenmannedwithroutinesequencesandESWANsequences.Thesubjectsweredividedinto6groupsaccordingtotheirage:GroupA(age20-29),GroupB(age30-31),GroupC(age40-49),GroupD(age50-59),GroupE(age60-69)andGroupF(age》70).Phasevaluewasmeasuredinbothsidesofputamenandglobuspallidus,andthecorrelationsbetweenthephasevalueandagewereanalyzed.Results(1)Thephasevaluehavenolenticulardifferenceintheputamenandglobuspallidus(P》0.05).(2)Nosignificantgender-relateddifferenceinthebrainironconcentrationwasfoundintheputamenandglobuspallidus(P》0.05).(3)Therewerenosignificantdifferenceinallagegroupsinputamenandglobuspallidus(P《0.05).(4)Nosignificantage-relateddifferenceinthebrainironconcentrationwasfoundintheputamenandglobuspallidus(P》0.05).ConclusionIrondepositionhavenolenticulardifferenceintheputamenandglobuspallidus,andtheputamenandglobuspallidushassignificantgender-relatedandage-relatedduringbrainaging.【Keywords]Magneticresonanceimaging;Brainirondeposition;Gender;age在健康人群的正常生长过程中，整个人脑组织会随着年龄的增长发生退化性改变[1】。随着我国老龄化人口的速度增长，伴随着老化所产生的脑形态及功能的研究越来越受到人们的关注。本文主要应用ESWAN(enhancedgradientechoT2star----本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---weightedangiography)扫描，研究正常脑老化过程中豆状核脑铁含量与侧别、性别、年龄之间的相关性，探索脑铁沉积的变化规律，为祌经退行性疾病如帕...