血必净注射液对脓毒性休克患者氧利用率、中心静脉血氧饱和度及乳酸影响的临床研究血必净注射液对脓毒性休克患者氧利用率、中心静脉血氧饱和度及乳酸影响的临床研究摘要:冃的:探讨血必净注射液(Xubi激nginjection)对脓毒性休克(SepticShock)患者氧利用率(oxygenutilizationcoefficient,O2UC)、中心静脉血氧饱和度(Centralvenousoxygensaturation,Scv02)和乳酸(Lacticacid,Lac)的影响,为血必净注射液在脓毒性休克的临床应用提供依据。方法:对符合纳入标准60例脓毒性休克患者随机分为治疗组(30例)和对照组(30例)o两组均给予西医常规治疗,治疗组同时给予血必净注射液静滴,对照组给予5%葡萄糖注射液静滴。分别在用药前,用药后2h、4h、6h、12h行动脉血及中心静脉血气分析,测定中心静脉血氧饱和度(Scv02)和乳酸(Lac),计算氧利用率(O2UC),釆用前瞻性自身前后及组间对照研究方法,收集数据进行统计分析。结果:①治疗前两组的Scv02、乳酸、氧利用率比较差异无统计学意义(P均)0.05);②治疗组用纱后4h、6h、12h的Scv02水平明显高于对照组,差异有统计学意义(P均<0.05);③治疗组用约后6h、12h乳酸浓度均低于对照组同时点的乳酸浓度,差异有统计学意义(卩〈0・05、P<0.01);④治疗组用药后2h、6h、12h的氧摄取率高于对照组,两组比较差异均有统计学意义(P均<0.05)o结论:在西医常规复苏治疗基础上加用血必净注射液治疗脓毒性休克患者,较单纯西医常规复苏治疗能更大程度地升高脓毒性休克患者的SCvO2,降低乳酸、增加氧利用率,从而改善感染性休克患者的全身氧代谢状况。关键词:脓毒性休克;血必净注射液;氧利用率;中心静脉血氧饱和度;乳酸:R631.4文献标识码:B:---本文来源于网络,仅供参考,勿照抄,如有侵权请联系删除---1673-7717(2012)01-0176-04ClinicalObservationonEffectsofXubi激ngInjectiononOxygenUtilizationCoefficient,CentralVenousOxygenSaturation(Scv02)andLacticAcidinPatientswithSepticShockMINGZi❷qiang,YULin❷ming,LVYin❷xiang(DepartmentofEmergencyandCriticalCareMedicine,XinchangPeople'sHospital,Xinchang315000,Zhe激ang,China)Abstract:Objective:TostudytheeffectofXubi激nginjectionon02UC>Scv02andLacticacidinpatientswithsepticshock.Methods:Sixtypatientswithsepticshockweredividedrandomlyintotreatmentgroup(n=30)andcontrolgroup(n=30)・Bothoftwogroupsweretreatedwithconventionaltherapy.PatientsinthetreatmentgroupweretreatedwithXubi激nginjectionsimultaneously.Whilepatientsinthecontrolgroupweretreatedwith5%glucoseinjection.Arterybloodandcentralveinbloodweredrawedforbloodgasanalysisbeforeandat2,4,6and12hoursaftertreatmentinpatientsofbothgroups.Centralvenousoxygenextractionrateweretested.Results:TherewerenosignificationdifferencesinScv02,lacticacidand02UCbetweentwogroupsbeforetreatment(allP>0.05).ThelevelsofScv02at4,6and12hoursaftertreatmentintreatmentgroupwereobviouslyhigherthanthoseincontrolgroup(allP〈0・05)・Andtheconcentrationoflacticacidat6and12hoursaftertreatmentintreatmentgroupwerelowerthanthoseintreatmentgroup(P<0.05、P〈0・01).The02UCat2,6and12hoursaftertreatmentintreatmentgroupwerehigherthanthoseincontrolgroup(allP〈0.05)・Conclusion:Contrasttoconventionalwesternresuscitationtherapy,Xubi激---本文来源于网络,仅供参考,勿照抄,如有侵权请联系删除---nginjectioncombinedwithconventionalwesternresuscitationtherapycanmorenotablyincreaseScv02,reducebloodlacticacid,increaseoxygenutilizationcoefficient,andimprovesystemicoxygenmetabolisminpatientswithsepticshock・Keywords:Septicshock;Xubi激nginjectionjoxygenutilizationcoefficient:Centralvenousoxygensaturation;Lacticacid脓毒性休克(Septicshock)是指严重感染患者经足量液体复苏仍持续低血压(收缩压<90mniHg或较基础水平下降幅...