急性一氧化碳中毒血栓前状态的检测及临床研究徐盈钟玲陈国兵（云南省第一人民医院/昆明医科大学附属昆平医院急诊ICU科云南昆明650032）【摘要】目的研究急性一氧化碳中毒患者血液流变学、凝血、抗凝及纤溶系统功能的变化。方法对31例急性一氣化碳中毒患者测定6项能反映血栓前状态的分子标志物。并检测全血高切粘度（&eta;bHr）、全血低切粘度（&eta;bLr）、血浆粘度（&eta;Pr）。结果与正常对照组比较，急性一氧化碳中毒患者AT-II1、PLg、t-PA活性均低于对照组，P<0.05。Hb含量、&eta;bL&reg;、&eta;bH&reg;、D-Dimer水平均明显高于对照组，P<0.05。t-PA活性下降，P<0.01。结论急性一氧化碳中毒患者血液为血栓前状态，具有高粘滞、高凝固、低抗凝、低纤溶性特点，血栓前状态指标的检测有助于判断一氧化碳中毒患者的病情，及早干预有利提高急性一氧化碳中毒的疗效。【关键词】一氧化碳中毒血液流变学凝血功能血栓前状态【中图分类号】R595【文献标识码】A【文章编号】2095-1752（2013）24-0364-02ClinicalSignificanceofMeasurementofPrethromboticStateinpatientswithAcutecarbonmonoxidepoisoningXuYing.ZhongLing.ChenGuobing.DepartmentofemergencyICU,Thefirstpeople&rsquo;shospitalofYunnanprovice,kunming650032,China.【Abstract】ObjectiveTostudythechangesofthehemorrheologycoagulationanticoagulationandfibrinolyticsystemduringAcutecarbonmonoxidepoisoning.MethodsSixparametersconcerningendotheliocytes,Plateletsandfibrinolysisweremeasuredin64casesofacutecarbonmonoxidepoisoningandbiuretmethodwholebloodviscosityinhighshearrate（&#331;pur）,Wholebloodinlowshearrate(&#331;plr),Plasmaviscosity(&#331;pr).Werealsomeasured.ResultsAscomparedwithnormalcontrols.TheactivitiesoftheAT-III，PLgandt-PAintheAcutecarbonmonoxidepoisoningpatientswerelowerthanthatofthecontrolgroup(P<0.05).ConclusionThebloodsoftheacutecarbonmonoxidepoisoningpatientsareintheprethrombotisstate,includinghyperviscosity,hypercoagulation,hypoanticoagulationandhypofibrinolyticfunction.Recognizigandcorrectingthechangesabove-mentionedcanhelptoimprovethetherapeuticeffectofacutecarbonmonoxidepoisoningandreducethefatalityrate.【Keywords]AcutecarbonmonoxidepoisoningHemorrhedogyAnticoagulativefunctionFibrinolvticPrathromboticstate【摘要】B的研究急性一氧化碳中毒患者血液流变学、凝血、抗凝及纤溶系统功能的变化。方法对31例急性一氧化碳中毒患者测定6项能反映血栓前状态的分子标志物。并检测全血高切粘度(&eta;bHr)、全血低切粘度(&eta;bLr)、血浆粘度(&eta;Pr)。结果与正常对照组比较，急性一氧化碳中毒患者AT-III、PLg、t-PA活性均低于对照组，P<0.05oFib含量、&eta;bL&reg;、&eta;bH&reg;、D-Dimer水平均明显高于对照组，P<0.05。t-PA活性下降，P<0.01。结论急性一氧化碳中毒患者血液为血栓前状态，具有高粘滞、高凝固、低抗凝、低纤溶性特点，血栓前状态指标的检测冇助于判断一氧化碳中毒患者的病情，及早干预有利提高急性-氧化碳中毒的疗效。【关键词】一氧化碳中毒血液流变学凝血功能血栓前状态【中图分类号】R595【文献标识码】A【文章编号】2095-1752(2013)24-0364-02ClinicalSignificanceofMeasurementofPrethromboticStateinpatientswithAcutecarbonmonoxidepoisoningXuYing.ZhongLing.ChenGuobing.DepartmentofemergencyICU,Thefirstpeople&rsquo;shospitalofYunnanprovice,kunming650032,China.【Abstract】ObjectiveTostudythechangesofthehemorrheologycoagulationanticoagulationandfibrinolyticsystemduringAcutecarbonmonoxidepoisoning.MethcdsSixparametersconcerningendotheliocytes,Plateletsandfibrinolysisweremeasuredin64casesofacutecarbonmonoxidepoisoningandbiuretmethodwholebloodviscosityinhighshearrate(&#331;pur),Wholebloodinlowshearrate(&#331;plr),Plasmaviscosity(&#331;pr).Werealsomeasure...