正常妇女孕早期血红蛋白浓度与妊娠期缺铁性贫血的相关性研究黄雅[1],朱丽仙[1],钟洁[1],周亚丽[2](1•昆明医科大学附属甘美医院产科云南昆明650011;2.昆明医科大学附属甘美医院妇科云南昆明650011)摘要:目的:探讨正常妇女孕早期血红蛋白浓度(Hb)与妊娠期缺铁性贫血(IDA)发生风险间的关系。方法:以2010年1月1口〜2013年6月30日在我院产科门诊系统规范产检至分娩的正常孕妇1846例为研究对象,检测其孕早期(孕10〜14周)、孕屮期(孕20〜28周)、孕晚期(孕37周〜分娩前)3个时段的Hb浓度,将研究对象按孕早期(孕10〜14周)Hb浓度分为四组,比较各组不同时段IDA的发生率。结果:孕早期Hb浓度在110g/L〜122g/LZ间的妇女在不同孕期发生IDA的风险均高于孕早期Hb浓度≥123g/L的妇女,其屮在孕屮期(孕20〜28周)IDA发病率为27.41%,在孕晚期(孕37周〜分娩前)IDA发病率为42.49%o结论:孕早期Hb浓度水平与IDA发生率存在负相关性,尤其在孕晚期更为明显,孕早期Hb浓度在110"L〜122g/LZ间的妇女在孕早期预防性补充铁剂,对预防在孕中期和孕晚期发生妊娠期缺铁性贫血有临床意义。关键词:缺铁性贫血,妊娠;血红蛋口StudyonthecorrelationbetweenhemoglobinconcentrationinnormalwomeninearlypregnancyandgestationalirondeficiencyanemiaHUANGYa[1],ZHULixian[1],ZHONGJie[1],ZHOUYali[2](l.Dept.ofObstetrics,AffiliatedCalmetteHospitalofKunmingMedicalUniversity,KunmingYunnan650011;2.Dept.ofGynecology,AffiliatedCalmetteHospitalofKunmingMedicalUniversity,KunmingYunnan650011)Abstract][Objective:Toinvestigatethenormalearlypregnantwomenhemoglobinconcentration(Hb)andgestationalirondeficiencyanemia(IDA)occurreneeoftherelationshipbetweenrisk.Methods:fromJanuary1,2010toJune30,2013inourhospitalgynecologyclinicsystemstandardizedbirthtodeliveryof1846normalpregnantwomenastheresearchobject,thedetectionofearlypregnancy(pregnancy10~14weeks),middlepregnancy(pregnancy20~28weeks),latepregnancy(gestationalweek37~beforedelivery)Hbconcentration3hourstheobjectofstudy,accordingtoearlypregnancy(pregnancy10~14weeks)concentrationofHbweredividedintofourgroups,theincideneeofIDAwerecomparedinthedifferentperiodoftime.Results:theconcentrationofHbinearlypregnancywomenbetween110g/Land122g/LwerehigherthaninearlypregnancyHbconcentrationis123g/LindifferentIDAriskduringpregnancyinwomen,whichinthemiddleofpregnancy(pregnancy20~28weeks)theincideneeofIDAwas27.41%,inthethirdtrimesterofpregnancy(37weeksgestationtodeliverybefore)theincideneeofIDArateof42.49%.Conclusion:earlypregnancyHbconcentrationlevelsandtheincideneeofIDAisnegativecorrelation,especiallyinthethirdtrimesterofpregnancyismoreobvious,theconcentrationofHbinearlypregnantwomenbetween110g/L~122g/Linearlypregnancypreventionofironsupplement,topreventinthesecondandthirdtrimestersofpregnancyoccurredinirondeficiencyanemiaclinicalsignificanee.Keyword:Irondeficiencyanemia,pregnancy;hemoglobin[中图分类号]R714.1[文献标志码]A[文章编号]缺铁性贫血(irondeficiencyanemia,IDA)是妊娠期最常见的贫血,占妊娠期贫血95%,属高危妊娠范畴[1]。根据世界卫生组织(WHO)标准和第八版教科书诊断标准,即妊娠各期孕妇外周血血红蛋白(hemoglobin,Hb)浓度<110g/L[2],即可诊断。鉴于妊娠期缺铁性贫血对母儿均可造成一定危害,孕期预防性补充铁剂以防止妊娠期缺铁性贫血的发生被人家日益重视,而在不发达的西部地区,不能全面检测血清铁蛋白的医疗机构,如何确定孕期补铁的时间是个问题。本研究通过冋顾性临床资料分析,探讨正常妇女孕早期血红蛋白浓度和与妊娠期缺铁性贫血发病风险间的关系,进一步为孕期预防性补充铁剂提供依据。1•资料和方法1・1研究对象选择2010年1月1日〜2013年6月30日在昆明市第一人民医院产科...