我院活血类中药注射剂的使用情况及其对策分析幽要］目的分析柳州市柳铁中心医院（以下简称“我院”）活血类中药注射剂的使用情况及其对策。方法收集我院2011年1月〜2015年12月药物不良反应（ADR）共403例，采用集中监测的方法对我院ADR的发生情况进行监测，统计我院活血类中药注射剂致不良反应患者的年龄分布、现有活血类中药注射剂品种的不良反应发生率、活血类注射剂所致ADR主要累及的系统或器官及临床表现等。结果403例ADR中，活血类中药注射剂致不良反应的患者共45例，不良反应发生率为11.2%，其中男19例，女26例，年龄23〜86岁，平均56.4岁，其中41〜60岁者（17例）居多，占总数的37.78%。我院常用的活血类中药注射剂品种前5名包括输血宁、血塞通、血栓通、灯盏细辛、灯盏花素，发生率分别为0.31%、0.25%、0.14%、0.13%、0.03%。45例活血类中药注射剂ADR报告显示，其主要累及的系统有皮肤及附件损害（30.00%），主要表现为皮疹、瘙痒、斑丘疹；其次为循环系统损害（25.00%），主要表现为胸闷、胸痛、血压升高、心悸、潮红、水肿。结论我院活血类中药注射剂不良反应的集中监测获得相关不良反应发生率不高，不良反应以皮肤及附件损害为主，且累及机体多个系统，其中以黄酮类为主要成分的舒血宁注射液使用最多。降低不良反应发生率应从综合干预的角度出发，加强应用知识的宣传，监管中药注射剂的质量，减少联合用药，并规范药品适用证。［关键词］活血类中药注射剂；药物不良反应；监测；对策［中图分类号］R286；R288［文献标识码］A［文章编号］1673-7210(2016)10(c)-0079-04［Abstract］ObjectiveToanalyzetheusingstatusanditscountermeasureofblood-activatingTCMinjectionsinLiutieCentralHospitalofLiuzhouCity(“ourhospital”forshort).MethodsTotalof403casesofadversedrugreactions(ADR)inourhospitalfromJanuary2011toDecember2015werecollected.Bythemethodofcentralizedmonitoring,theoccurrenceofADRinourhospitalwasmonitored,theagedistributionofpatientswithadversereactionsresultfromblood-activatingTCMinjections，theincidenceofexistingvarietiesofblood-activatingTCMinjections,andthemainsystemsororgansandclinicalfeaturesofADRresultfromblood-activatingTCMinjectionswerecounted.ResultsAmong403caseswithADR,therewere45caseswithADRresultfromblood-activatingTCMinjections,theincidenceofadversereactionswas11.2%,amongwhom，malehad19cases，femalehad26cases，23-86yearsold,withanaverageageof56.4years,17casesof41-60yearsoldpatientswereinthemajority,accountedfor37.78%ofthetotalnumber.Thefirst5blood-activatingTCMinjectionswereShuxuening,Xuesaitong，Xueshuantong,DengzhanXixin,breviscapine，theincidenceofwhichwas0.31%,0.25%，0.14%，0.13%，0.03%respectively.Thereportsof45casesofADRresultfromblood-activatingTCMinjectionsshowedthat，themainlyinvolvedsystemswereskinandaccessoriesinjury(30.00%),showingrash,pruritus,maculopapule；thenextinvolvedsystemswerecirculatorysysteminjury(25.00%)，showingchestdistress,chestpain，elevationofbloodpressure，palpitation，flushing,edema.ConclusionTheincidenceofrelatedadversereactionsobtainedfromthecentralizedmonitoringofadversereactionsresultfromblood-activatingTCMinjectionsinourhospitalisnotveryhigh，themainadversereactionsareskinandaccessoriesinjury,andmultiplesystemsareinvolved，amongwhich，theusageofShuxueningInjectionwithflavonoidasthemainingredientsismorefrequency.Decreasingtheincidenceofadversereactionsshouldstartfromtheviewofcomprehensiveintervention，suchasstrengtheningthepublicityofapplicationknowledge，takingchargeofthequalityofTCMinjections,reducingdrugcombination,andcorrectingtheindicationofdrugs.［Keywords］Blood-activatingTCMinjections；Adversedrugreactions；Monitoring；Count...