MRI增强扫描在周围型肺癌微波消融治疗疗效评价中的初步研宄李慎江(屮国人民解放军第88医院放射科山东泰安271000)【摘要】A的：初步探讨MRI增强扫描在评价周围型肺癌微波消融治疗疗效屮的作用。方法：对27例周围型肺癌患者行MR增强扫描，分别在25s及130s行胸部扫描。记录病灶病灶治疗前、治疗后、治疗后强化区最大单径之和、治疗后未强化区最大单径之和及治疗后空洞最大|Aj径之和。在磁共振工作站分别测量病灶面积、治疗后病灶未强化区面积及空洞面积。使用均数间方差检验、配对t检验进行统计学分析。结果：27例屮18例(66.67%)表现为周边强化的偏心性空洞病变；7例(25.93%)表现为无空洞坏死病灶；1例(3.70%)表现为周边强化的无空洞病变；1例(3.70%)表现为混杂强化。治疗后病灶未强化区面积占病灶面积的77.51%。病灶治疗前、治疗后、治疗后强化区最大单径之和、治疗后未强化区最大单径之和及治疗后空洞最大N径之和分别为(3.67&plusmn;1.73)、(4.11&plusmn;1.63)、(0.86&plusmn;1.27)、(3.62&plusmn;1.60)、(2.31&plusmn;1.92)cm,差异有统计学意义(f=17.761,p<0.001)。治疗后病灶最大单径之和与治疗前病灶最大单径之和无显著差异(p=0.331〉0.05＞。治疗后病灶强化区最大单径之和明显小于治疗前病灶最大单径之和(p<0.001)。治疗后病灶未强化区最大单径之和与治疗后病灶最大单径之和无显著差异(p=0.278〉0.05)。治疗后病灶未强化区最大单径之和大于空洞最大内径之和(p=0.004<0.05)o结论：周围型肺癌微波消融治疗后病灶人部分发生了坏死，MRI增强扫描能反映肺癌的的血流动力学信息，是评价肺癌微波消融治疗疗效的有效方法。【关键词】肺癌；微波；消融；磁共振成像；图像增强；疗效评价【屮图分类号】R730.5【文献标识码】A【文章编号】2095-1752(2015)12-0115-03Preliminaryassessingmicrowaveablationresponseinbronchogeniccarcinomawiththree-phasecontrastmaterial-enhancedmagneticresonanceimaging【Abstract】ObjectiveToevaluatethefeasibilityandeffectivenessofcontrastmaterial-enhancedmagneticresonanceimaging(MRI)inassessingmicrowaveablationresponseinperipheralbronchogeniccarcinomapreliminarily.Methods27Patientswithperipheralbronchogeniccarcinomaaftermicrowaveablationunderwentcontrastmaterial-enhancedmagneticresonanceimaging.Scanswereobtainedat25and130secondsrespectivelyafternonioniccontrastmaterialwasadministratedviatheantecubitalveinatarateof2mL/secbyusinganautoinjector.Thesumofthetumorlongestdiameters(LD)priortotreatment,aftertreatment,thesumofthepost-treatmenttumorenhancementareaLD，thesumofthepost-treatmenttumornoenhancementareaLDandthesumofthepost-treatmenttumorcavityareaLDwererecorded.Theareaofthetumors，thesumofthepost-treatmenttumornoenhancementareaandthesumofthepost-treatmenttumorcavityareaweremeasuredonMRIworkstationwitha5megapixel(MP)liquidcrystaldisplays(LCDs)respectively.ThesignificanceofthedifferenceamonggroupswasanalyzedbymeansofANOVA,studentttest.ResultsEighteencasesamong27(66.67%)appearedlesionwitheccentriccavityandperipheralirregularenhancement.Sevencases(25.93%)appearedlesionwithoutenhancementandcavity.Onecase(3.70%)appearedperipheralirregularenhancementlesionwithoutcavityinside.Onecase(3.70%)appearedheterogeneousenhancement.Thesumofthepost-treatmenttumornoenhancementareawasabout77.51%oftheareaofthetumors.Thesumofthetumorlongestdiameters(LD)priortotreatment,aftertreatment,thesumofthepost-treatmenttumorenhancementareaLD，thesumofthepost-treatmenttumornoenhancementareaLDandthesumofthepost-treatmenttumorcavityareaLDwere(3.67&plusmn;1.73)、(4.11&plusmn;1.63)、(0.86&plusmn;1.27)、(3.62&plusmn;1.60)、(2.31&plusmn;1.92)cmrespectivelyandtherewerestatisticallysignificantdifferencesamongthem(f=17.761,p<O.O...