榄香烯注射液在儿童颅内肿瘤及实体瘤颅内转移病例中的临床研究胡慧敏张伟令黄东生王一卓张谊朱霞洪亮刘爱平张品伟李静易优文圆首都医科大学附属北京同仁医院儿科北京100176【摘要】目的本文研究榄香烯注射液在儿童颅内实体瘤及恶性实体瘤颅内转移病例化疗屮的辅助治疗作用•方法2005年9月一2014年12月收集经病理确诊的儿童颅内实体瘤12例,恶性实体瘤颅内转移22例•所有病例随机分成研究组(常规化疗+榄香烯注射液)和对照组(常规化疗组)两组•分析化疗期间以及化疗后骨髓抑制、毒副作用以及不良反应•结果(1)颅内实体瘤12例,其屮髓母细胞瘤10例,胶质瘤1例，星形细胞瘤1例，随机分成研究组8例，对照组4例•实体瘤颅内转移病例22例,其屮神经母细胞瘤颅内转移6例，视网膜细胞瘤颅内转移16例，随机分成研究组10例，对照组12例.(2)化疗后骨髓抑制情况:研究组化疗后白细胞最低值0•40×l09/L,对照组口细胞最低值0・07×109/L,研究组与对照组的差异具有统计意义(X2=4・1,P=0・02);研究组外周血白细胞恢复中位时间为(9.5±1・3)d,对照组为(11.9±2.4)d”研究组与对照组的差异具有统计意义(X2=3.9,P=0・025).(3)不良反应分析:研究组不良反应发生较对照组少,差异有统计学意义(P<0.05).结论榄香烯注射液联合常规化疗可明显缓解颅内肿瘤及实体瘤颅内转移患儿化疗期间的骨髓抑制，明显减轻不良反应，具有一定临床应用价值.【关键词】颅内肿瘤;实体瘤;转移;儿童;榄香烯注射液TheCIinicalStudyofElemenelnjectioninChildrenwithlntracranialTumorandSolidTumorwithlntracranialMetastasisAbstract:ObjectiveTostudytheadjuvanttherapywithelemeneinjectioninchemotherapyinchildrenwithintracranialtumorandmalignantsolidtumorwithintracranialmetastasis.Methodsfrom2005Septemberto2014December,atotalof12caseswithpathologicallyconfirmedintracranialtumor,22casesofintracranialmetastasiswithmalignantsolidtumor.Allpatientswererandomlydividedintotwogroups,theonewasthestudygroup(chemotherapy+Elemenelnjection)andtheotherwasthecontrolgroup(chemotherapygroup)-SuppressionofbonemarrowduringchemotherapyandtoxicsideeffectsandadversereacGtionsafterchemotherapywereanalyzed.Results(1)12casesofintracranialtumors’included10casesofmedulloblastoma,1caseofglioma,1caseofastrocytoGma,wererandomlydividedintothestudygroupwith8casesandthecontrolgroupwith4cases.22casesofintracranialtumormetastasisincluded6casesdiagGnosedasneuroblastomaand16casesthosewerediagnosedasretinoblastoma.These22caseswererandomlydividedinto10casesinthestudygroupand12casesinthecontrolgroup.(2)bonemarrowsuppressionafterchemotherapy:astudygroupofwhitebloodcellsafterchemotherapy:thelowestvalueofWBCinthestudygroupwas0.40x109/L,thevalueinthecontrolgroupwas0•07x109/L.Thedifferenceshowedthestatisticalsignificancebetweenthethetwogroups(X2=4.1,P=0•02).Mediantimeofperipheralwhitebloodcellsrecoverywas(9•5+1.3)daysinthestudygroup’andthetimewas(11.9+2.4)daysintheconGtrolgroup.Thedifferenceshowedthestatisticalsignificancebetweenthestudygroupandthecontrolgroup(X2=3.9,P=0.025).(3)Adversereaction:adGversereactionbetweenthetwogroupswereanalyzedandthedifferencewasstatisticallysignificant(P<0.05).ConclusionElemenelnjectioncombinedwithconventionalchemotherapycansignificantlyrelievebonemarrowsuppressionafterchemotherapytochildrenwiththeintracranialtumorandsolidtumorwithinGtracra【nKiealymwoertadsst]asis,anditcanalleviatetheadversereaction.Elemenelnjectionhascertainvalueofclinicalapplication.intracranialtumor;solidtumor;metastasis;children;elemeneinjection【中图分类号】R656・1【文献标识码】B【文章编号】1008—6315(2015)12—1058—02颅内肿瘤是仅次于白血病的儿童第二位肿瘤，...
