奉化市普通人群非酒精性脂肪肝患病率的流行病学调查周建芳1童云龙1吕其芬1俞健侠1李玉龙2丁青侃3(1浙江奉化市人民医院315500；2浙江奉化市裘村卫生院315500；3浙江奉化市疾病控制中心315500)【中图分类号】R195【文献标识码】A【文章编号】1672-5085(2010)34-0450-03【摘要】目的调查奉化市普通人群非酒精性脂肪肝患病率及其主要的危险因素。方法通过多阶段分层随机抽样，对奉化市城区5个街道6个镇18岁以上居民进行调查，调查的内容涉及问卷调查、体格检查、牛化检测及肝胆B超检查。结果95567例完成调查，占奉化市总人口的22.2%,非酒精性脂肪肝患病率为14.18%,女性明显高于男性，非酒精性脂肪肝组收缩压、舒张压、体重指数、空腹血糖、超重肥胖、高血糖、血脂异常和高血压患病率均明显高于对照组(P<0.01),多因素分析结果显示，男性、文化程度低、高血压、肥胖、腰臀比、腰围以及甘油三酯和空腹血糖升高等8项指标与脂肪肝密切相关。结论奉化市普通人群非酒精性脂肪肝患病率与超重肥胖及其相关的多元代谢紊乱关系密切。【关键词】非酒精性脂肪肝流行病学患病率危险因素EpidemiologicalsurveyofprevaleneethenonalcoholicfattyliverinageneraladultpopulationoffenghuaZhouJian・Fang,TongYurvLong,LvQi-finyuxia-jianLiyu-longDingqing-kanetal.FenghuaPeople'sHenghua,Hospital,Henghua,315500,ZhejiangChina【Abstract】ObjectiveToinvestigatetheprevalenceandmajorriskfactorsofnonalcoholicfattyliveramonggeneraladultresidentsinfenghua.MethodsAcross-sectionalsurveywithmultiple-stagestratifiedclusterandrandomizedsamplingwasperformed.AIIresidentsaged18andabovewereinvitedtoparticipateinthesurvey.Theycamefrom5street,6pieceofDistrict.Questionna---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---ire,physicalexamination,biochemistrytestandultrasonographicexaminationofliverandgallbladderwereundertaken.・ResultsAtotalof95567residentstookpartinthesurvey,whichwas22.2%offenghuamunicipalresidents.Theprevaleneeofnonalcoholicfattyliverwas14.18%.Theprevaleneeofnonalcoholicfattyliverinfemaleswasmorehigherthanmales.Themeansystolicbloodpressure(SBP),diastolicbloodpressure(DBP),bodymassindex(BMI),fastingserumglucoselevel,triglyceride(TG),totalcholesterol(Tch)‘andtheprevaleneeofultra-bodymass,obesity,highserumglucose,dyslipidemiaandhypertensioninthenonalcoholicfattylivergroupwassignificantlyhigherthanthoseinthecontrolgroup(allP<0.01).Logisticregressionanalysisdemonstratedthattheprevalenceofnonalcoholicfattyliverwaspositivelycorrelatedtoeightriskfactors,!ncludingmale,culturelevel,hypertension,obesitywaist-to-hipratio,waistline,TG,fastingserumglucose.ConclusionThereisnonalcoholicfattyliveramongadultresidentsinfenghua.Metabolicdisorderssuchasultra-bodymassandobesity,highserumglucose,dyslipidemiaandhypertensionarecloselyassociatedinfenghua.【Keywords］nonalcoholicfattyliverepidemiologicalsurveyprevalenceriskfactors非酒精性脂肪肝(nonalcoholicfattyliver,NAFLD)已成为发达国家和发展中国家共同问题，在发达国家其死亡率排在第5位，仅次于心脏病、脑血管意外、肺部疾病和恶性肿瘤之后。近年来，随着饮食结构和生活习惯的改变，我国的NAFLD的发病率明显上升。NAFLD往往与糖尿病、肥胖、血脂紊乱、高胰岛素血症等代谢综合征(metabolicsyndrome,MS)症状并存，其发病与胰岛素抵抗(Insulinresistance,IR)密切相关,NAFLD的发病涉及到遗传和环境等因素,因此，NAFLD的流行病学研究受到普遍关注［1］。为此我们对奉化市普通人群NAFLD患病现状进行调查，并探讨其主要危险因素。1资料与方法1.1研究对象为奉化市区成年常住居民，奉化市城区5个街道6个镇共45万人口。采用多阶段分层随机整群抽样的方法，对本市区内18岁以上的---本文来源于网络，仅供...