环磷腺苷葡胺对老年充血性心力衰竭患者血浆胱抑素C、心功能及脑钠肽的影响分析苟定芬（四川省隆昌县人民医院642150）【摘要】R的：分析环磷腺苷葡胺治疗老年充血性心力衰竭（CHF）的疗效及对患者血浆胱抑素（CysC）、心功能及脑钠肽（BNP）的影响。方法：将我院收治的82例老年CHF患者随机分为观察组41例和对照组41例。对照组患者行CHF常规治疗，观察组患者在常规治疗的棊础上行环磷腺苷葡胺治疗。评价2组患者的临床治疗效果，检测患者治疗前后血浆CysC、BNP的指标水平及心功能指标水平。结果：观察组患者临床治疗的总有效率为87.80%，对照组为73.17%,2组比较，差异具有统计学意义印<0.05）。2组患者的心功能左室射血分数（LVEF）、左室舒张末期内径（LVD）、左室收缩末期内径（LVS）指标水平较治疗前均改善，但观察组患者的改善幅度大于对照组（P<0.05）。同时，治疗后，2组患者的血浆CysC和BNP指标值较治疗前均不降，但观察组患者各指标的不降幅度均大于对照组（P<0.05）。结论：在常规治疗的基础上联合环磷腺苷葡胺治疗可通过提高患者血浆CysC,BNP指标水平及心功能的改善效果而促进CHF临床整体治疗效果的提高，在CHF的临床治疗中具有良好的应用价值。【关键词】充血性心力衰竭；环磷腺苷葡胺；胱抑素C;心功能；脑钠肽【屮图分类号】R541.6+2【文献标识码】B【文章编号】1003-5028（2015）7-0074-02AnalysisoftheeffectsofmeglumineadenosinecyclophosphateonurinaryinhibitionC,cardiacfunctionandplasmabrainnatriureticpeptidelevelsofElderlypatientswithcongestiveheartfailure[Abstract]Objective:toanalyzeofmeglumineadenosinecyclophosphatetreatmentthecurativeeffectofelderlycongestiveheartfailure(CHF)andinplasmainpatientswithbladderinhibition(CysC),cardiacfunctionandtheeffectofbrainnatriureticpeptide(BNP).Methods:ourhospital’s82casesofelderlypatientswithCHFwererandomlydividedintotheobservationgroup(41cases)andthecontrolgroup(41patients).ThepatientsofcontrolgroupweretreatedbyCHFroutinetreatment,onthebasisofroutinetherapy,thepatientsofobservationgroupweretreatedbymeglumineadenosinecyclophosphate.2groupsofpatientswiththeclinicaltreatmenteffectwereevaluated,beforeandaftertreatment,thepatient’slevelofserumCysC,BNPindexandcardiacfunctionweredetected.Results:observationgroupofpatientswithclinicaltreatmentthetotaleffectiveratewas87.80%,controlgroupwas73.17%,thecomparisonoftwogroups,statisticallysignificantdifference(P<0.05).Twogroupsofcardiacfunctioninpatientswithleftventricularejectionfraction(LVEF),leftventricularend-diastolicdiameter(LVD),leftventricularendsystolicdiameter(LVS)indexlevelbeforetreatmentwereimproved,buttheobservationgroupofpatientsimproveamplitudewasgreaterthanthecontrolgroup(P<0.05).Atthesametime,aftertreatment,thepatientsoftwogroupsofCysCandplasmaBNPindexwasdecreased,thebuttheindexdeclineofobservationgrouppatientsweregreaterthanthecontrolgroup(P<0.05).Conclusion:onthebasisofconventionaltreatmentcombinedmeglumineadenosinecyclophosphatetreatmentcanimprovethepatients1serumCysC,BNPindexlevelandcardiacfunctionimprovementandimproveCHFclinicaltreatmenteffectofthewhole,intheclinicaltreatmentofCHFhasgoodapplicationvalue.[Keywords]congestiveheartfailure;meglumineadenosinecyclophosphate;CystatinC;Cardiacfunction;Brainnatriureticpeptide充血性心力衰竭(CHF)是因心室泵血功能下降致心排血量不足而引发的以组织、器官血液灌注障碍、心脏血液输出量减少为主要病理基础的心室功能不全临床综合征，同时也是各类心脏病发展的终末阶段。近年来，随着临床医学对该病发病机制的深入研究，关于心血管相关因子及指标在该病发生、发展中的参与机制成为临床研宄的热点。其中，血浆胱抑素（CysC）是反映CHF患者心力衰竭病情...
