・临床研究DNA修复基因XPD遗传多态性与肺癌易感性关系的rweta分析贾志芳尹智华关鹏周宝森[摘要】背景与目的研究表明DNA损伤修复基因.人类着色性干皮病基因D(xerodermapigmentosumgroupD,XPD)多态性与肺癌的易感性有关，但各研究结论不一，本研究拟通过meta分析，定駅地评价XPD312和751位点基因多态性与肺癌的关系。方法全面检索相关文献，按纳入标准对文献进行筛选后提取相关信息，然后在StatalO软件中按照me加分析流程，选择合适方法计算合并的OR值及95%可信区间，并进行敏感性分析和发衣偏倚的估计。结果本研究纳入国内外22篇合格文献，其中XPD312位点15篇.XPD751位点20篇。合并结果显示，携带XPD312Asn/Asn突变荃因和患肺癌的危险性是野生5Usp/Asp的1.18倍(9596CI：1.03-134,P=0.018)；XPD751位点突变基因型也与肺癌危险性升高有关(Lys/GlnOR=4・09,95%CI:1.02-1.18；Gln/GInOR=1.24,9596CI:1.10-L41)。亚组分析显示XPD751与肺癌的关联性仅见于欧美人群。漏斗图和Eggert回归分析均未发现明显的偏倚。结论XPD基因312和751位点的突变与肺癌的易感性升高有关。【关键词】肺肿瘤；人类着色性干皮病基因D；彷也分析；基因多态性[中图分类号】R734.2DOI:10.3779/j.issn.l009-3419.2009.10.0STheAssociationbetweenPolymorphismsofXPDandSusceptibilityofLungCancer:AmetaAnalysisZhifengJIA,ZhihuaYIN,PengGUAN,BaosenZHOUDepartmentofEpidemiology,KeyLaboratoryofCancerEtiologyandPreventionofLiaoningProvince,SchoolofPublicHealth,CenterforEvidenceBasedMedicine,ChinaMedicalUniversity,Shenyang110001,ChinaCorrespondingauthor：BaosenZHOU,E-mail：bszhou^)mail.cmu.edu.cn[Abstract]BackgroundandobjectiveManystudiesconcludedthatthepolymorphismsofXPDwereinvolvedintheriskoflungcancer.However,severalotherstudiessuggestednoassociation.ToexplorewhetherthepolymorphismsofXPDcontributetothegeneticsusceptibilitytolungcancer,wecarriedame忆-analysisbasedonthepublishedworks.MethodsAllworksrelatedtoXPDandlungcancerriskweresearchedandcarefullyselected・IhegenotypefrequenciesofXPDandrelatedvariableswereabstractedandthepooledORswerecalculatedaftertheheterogeneitytestwiththesoftwareStata10.Publicationbiasandsensitivitywereevaluatedatthesametime.ResultsTwenty-twostudieswereincludedaccordingtotheselectioncri-teriafofwhichfifteeninvestigatedthecodon312ofXPDandtwentystudiedthecodon751.ThepooledORofsusceptibilitytolungcancerwithXPD312Asn/AsngenotypecomparedtothewildAsp/Aspwere1.18(95%CI:1.03-1.34,P=0.018).AndthepolymorphismsofXPDcodon751werealsoassociatedwithincreasedlungcancerrisk(Lys/GlnOR=1.09,95%CI:1.02-1.18；Gln/GInOR=1.24,95%CI：1.10-1.41).However,subgroupanalysisindicatedthattheassociationbetweenXPD751andlungcancercouldonlybefoundinEuropeansandAmericans・Thepublicationbiasanalysishadnostatisticallysignificantresults・ConclusionPolymorphismsofXPDcodons312and751seemtobeinvolvedinelevatedriskoflungcancer.【Keywords]Lungneoplasms；XerodermapigmentosumgroupD(XPD);mefa-analysis；GeneticpolymorphismThisstudywassupportedbygrantsfromtheNaturalScienceFoundationofLiaoningProvince(toBaosenZHOU)(No.20072103),LiaoningProvincialDepartmentofEducationGrant(toBaosenZHOU)(No.2008S232)andNationalNaturalScienceFoundationofChina(toBaosenZHOU)(No.30471493)・本研究受辽宁省自然科学基金(No・20072103).辽宁省教育厅高校車点实验室项目(No・2008S232)和国家自然科学基金(No.30471493)资助作者单位：110001沈阳，中国医科大学公共卫生学院流行病学教研室，辽宁省高校肿瘤病因与预防重点实验室，中国医科大学循证医学中心(通讯作者：周宝森，E-mail：bszhou^)mail.cmu.edu.cn)无论在中国还是全球范围内，肺癌都是发病率和死亡率居首位的恶性肿瘤⑴。研究表明，肺癌...