基于真实世界研究“化痰活络法”对脑梗死后轻度认知障碍患者PRO量表的影响(1•陕西省中医医院陕西西安710003；2•西电公司西安高压开关厂医院陕西西安710077)【摘要】冃的：观察化痰活络法对脑梗死后轻度认知功能障碍(痰瘀阻窍型)患者在真实世界研究(RWR)中的临床疗效。方法：采用RWR方法纳入脑梗死后轻度认知障碍患者，非随机开放式分为治疗组和对照组，两组均给予内科基础治疗，治疗组给予化痰活络饮200ml,2次/口、对照组给予口服尼麦角林片10mg/次，3次/口。连续治疗1个月。观察治疗前后两组组内和组间患者报告的临床结局(PRO)、中医症征积分变化及化痰活络饮在真实世界中对认知障碍患者预后的影响。结果：1.、临床总疗效:治疗组总有效率为84.00%,显效率为28.00%；对照组总有效率50.00%,显效率为12.00%,两组总疗效统计有显著差异(p《0.05)。2、患者报告的临床结局(PRO)：治疗后两组组间差异明显(p《0.05)；试验组治疗前后组内差异明显(pt;0.05)；对照组治疗前后组内差异不明显(p》0.05)o3.中医症征积分：治疗后两组组间差异明显(p《0.05)；试验组治疗前后组内差异明显(p《0.05)；对照组治疗前后组内差异不明显(p》0.05)o结论：化痰活络饮能够提高脑梗死后轻度认知功能障碍患者Pro量表得分、显著降低中医症征枳分，提示“化痰活络法”可改善认知障碍患者的临床结局，表明在真实世界研究中，化痰活络法是治疗脑梗死后轻度认知障碍患者的有效法则【关键词】轻度认知功能障碍；脑梗死；化痰活络法；真实世界研究；PRO量表【】R749.1【文献标识码】A【】1004-6194(2015)02-0001-02[abstract]objective：Toobservethephlegmadjustablemethodformildcognitivedysfunctionaftercerebralinfarction(typeofphlegmandbloodstasisresistaneeandtheorifices)patientsintheclinicalcurativeeffectintherealworldresearch(RWR).Methods：PatientswithmildcognitiveimpairmentaftercerebralinfarctionwereenrolledinthroughtheRWRmethodanddividedintotreatmentgroupandcontrolgroupintheopenrandomly.Twogroupsweregivenmedicalfoundationtreatment,the---本文来源于网络，仅供参考，勿照抄，如有侵权请联系删除---patientsintreatmentgroupweregivenphlegmadjustabledrink200ml,2/day,andthepatientsincontrolgroupweregivenoralergotLinpieceof10mg/time,3/dayfor1months.Toobservetheinflueneeonpatientsreportoutcome(PRO)withintwowayofclinical,TCMsyndromeintegralchangeandphlegmadjustabledrinkintherealworldimpactontheprognosisofpatientswithcognitiveimpairmentbeforeandaftertreatmentintwogroups.Results1,clinicalcurativeeffect:thetotaleffectiverateintreatmentgroupwas84.00%,sign讦icantefficiencyis28.00%;thetotaleffectiverateinthecontrolgroupwas50.00%,sign讦icantefficiencyis12.00%,thereissignificantstatisticaldifferencesofthetotalcurativeeffectintwogroups(p《0.05).2,patientsreportoutcome(PRO):thereissignificantstatisticaldifferencesintwogroups(p《0.05);Thedifferencesinexperimentalgroupbeforeandafterthetreatmentgroupwasobviously(p《0.05);Noobviousdiffereneewithinthecontrolgroupbeforeandaftertreatmentgroup(p》0.05).3,TCMsyndromeintegral,thereissignificantstatisticaldifferencesintwogroups(p《0.05);Thedifferencesinexperimentalgroupbeforeandafterthetreatmentgroupwasobviously(p《0.05);Noobviousdiffereneewithinthecontrolgroupbeforeandaftertreatmentgroup(p》0.05).Conclusion:phlegmadjustabledrinkcanimproveProscalescoreandreducetheTCMsyndromesignificantlyinpatientswithmildcognitivedysfunctionaftercerebralinfarction」tcanimproveclinicaloutcomeinpatientswithcognitiveimpairment,showthatinthestudyoftherealworld,phlegmisadjustablemethodinthetreatmentofmildcognitiveimpairmentaftercerebralinfarctionpatientswitheffectiverule.研究显示⑴脑卒中后2年内发生轻度认知...