铁皮石斛对高血压左室肥厚的病理研究【摘要】目的探?铁皮石斛对自发性高血压大鼠血压、左室重量指数、心肌组织病理改变及在左室肥厚中所起的作用。方法采用自发性高血压大鼠（SHR）和正常血压对照组大鼠（WKY）作为研究对象，将32只12周龄SHR随机分成实验对照组（SD组）、铁皮石斛低剂量组（SL组）、铁皮石斛中剂量组（SM组）、铁皮石斛高剂量组（SH组），每组8只，另8只12周龄WKY为空白对照组，采用尾动脉血压仪测量大鼠的收缩压和舒张压，连续药物干预6周后，处死大鼠，称体重、心脏重量和左室重量，计算出心脏指数（CI）和左室重量指数（LVMI）,取心肌组织做病理HE染色，观察大鼠心肌细胞的病理改变。结果与对照组比较，第12周、14周及16周SHR大鼠收缩压和舒张压明显下降（P〈0.05）,第16周SD组、SL组与SI1组间的大鼠C1和LVMI比较，差异有统计学意义（P<0.05）,各治疗组CI、LVMI.心肌细胞直径、周长及面积随剂量增加而减小（P〈0.05）。结论铁皮石斛治疗高血压效果显著，能有效控制血压水平，扭转心室重构等病理改变。【关键词】铁皮石斛；高血压；左室肥厚中图分类号：R544.1文献标识码：AD0I:10.3969/j.issn.10031383.2017.01.013Anpathologicalstudyofdendrobiumcandidumonleftventricularhypertrophy[HJ1*2][HJ]WANGJunbaol,PANXingshou2,HUANGZhaohe2(1.GraduateSchool,2.CardiovascularDepartmentofAffiliatedHospital,YoujiangMedicalUniversityforNationalities,Baise533000)[HJ2][HJ][AbstractJObjectiveToexploreinfluenceofdendrobiumcandidumonbloodpressure,leftventricularweightindex,pathologicalchangesofmyocardialtissueofspontaneouslyhypertensiverataswellasonleftventricularhypertrophy.MethodsSpontaneouslyhypertensiverats(SHR)andnormotensivecontrolrats(WKY)wereselectedasresearchobjects・Thirtytwo12weekoldSHRwererandomlydividedintoexperimentalcontrolgroup(SDgroup),1owdosedendrobiumcandidumgroup(SLgroup),middledosedendrobiumcandidumgroup(SMgroup)andhighdosedendrobiumcandidumgroup(SIIgroup),with8ratsineachgroup.Andtheothereight12weekoldWKYwereselectedasblankcontrolgroup・Systolicbloodpressureanddiastoliebloodpressureweremeasuredbytailarterybloodpressureapparatus・After6weeksofcontinuousdrugintervention,ratsweresacrificed,andweight,heartweightandleftventricularmassaswellascardiacindex(CI)andleftventricularmassindex(LVMI)worecalculated.Inaddition,myocardialtissuewastakenforpathologicalHEstaining,pathologicalchangesofmyocardialcellsinratswereobserved・ResultsComparedwiththecontrolgroups,systolicbloodpressureanddiastolicbloodpressureofSHRonweek12,weekidandweekl6decreasedsignificantly(P<0.05)・DifferenceofCIandLVMIonweek16amongtheSBgroup,theSLgroupandtheSHgroupwasstatisticallysignificant(P<0.05).Meanwhile,CI,LVMI,diameter,perimeterandareaofmyocardialcellsinthetreatmentgroupsdecreasedwiththeincreaseofdoses(P<0.05)・ConclusionDondrobiumcandidumfortreatmentofhypertensionhassignificanteffect,whichcaneffectivelycontrolthebloodpressurelevel,reverseventricularremodelingandotherpathologicalchanges.【Keywords】dendrobiumcandidum；hypertension；leftventricularhypertrophy高血压目前已是一个全球流行性的公共卫牛问题，全世界约有四分之一人口患此病［1］,同时高血压也是一种最常见的心血管致死性疾病，在没有出现并发症和靶器官损害之前最重要的一点在于预防。因为高血压患病率高，由它所导致的心血管疾病风险增加的同时，脑血管疾病和肾脏疾病也相应增加［2〜3］，其最常见的靶器官损害为心、脑、肾，而在心脏损害中，最早出现的是左室肥厚。近年来铁皮石斛在降低血糖、降压、降脂、提高免疫力、抗肿瘤方面取得了一定进展［4］。本实验采用自发性高血压大鼠（SHR）和正常血压对照组大鼠（WKY）为实验对象，予铁皮石斛干预6周，观察SHR大...