急性脑梗死患者纤维蛋白原功能与自由基SOD、MDA的临床研宄(1柳州市柳铁屮心医院神经内科广西柳州545007)(2柳州市柳铁屮心医院血液科广西柳州545007)(3柳州市柳铁屮心医院老年病科广西柳州545007)(4柳州市柳铁屮心医院检验科广西柳州545007)摘要】目的：探讨纤维蛋白原功能(fibrinogenfunctionAnticoagulant,Fg)、白由棊SOD和MDA在急性脑梗死发病屮的作用。方法.•按CCS评分将100例急性缺血性脑卒屮病人分为轻型组、屮型组和重型组，并设立对照组100名，分别采用双抗体夹心ELISA法、黄嘌呤氧化法和比色法动态测定脑梗死组及对照组发病后或入组后第1天、10天外周血浆Fg和SOD、MDA水平，分析其关系。结果：脑梗死组各时间点血浆Fg的水平明显高于正常对照组(P<0.01h脑梗死组发病第1天，SOD水平明显低于对照组，MDA水平明显高于对照组(P<0.01),在10天，两组比较无显著性差异；急性脑梗死患者血浆Fg水平在发病第1、10天随着病情严重程度而升高，三组比较有显著性差异(P<0.01),而SOD和MDA水平只在发病第1天才与病情严重程度有变化(P<0.01)。结论：Fg、MDA和SOD共同参与脑梗死急性期血管病理损伤过程，Fg可作为评估急性脑梗死患者病情轻重和预后的客观指标。【关键词】急性脑梗死；纤维蛋A原功能；超过氧化物歧化酶；丙二醛【屮图分类号】R446【文献标识码】A【文章编号】2095-1752(2015)35-0114-02AClinicalStudyonAcutecerebralinfarctionfibrinogenfunctionandFreeRadicalsSOD,MDAHejianmingl,ZhuMingxia2,Xuhong3,Yangdongyi3,WeiIiumei4(1.DepartmentofNeurology,2.DepartmentofHematology,3.DepartmentofGeriatrics,4.DepartmentofClinicalLaboratory,LiuLiuzhouRailwayCentralHospital,LiuZhuGuangXilChina.545007)【Abstract】ObjectiveToinvestigatethefunctionoffibrinogen(fibrinogenfunctionAnticoagulant,Fg),FreeRadicalsSODandMDAintheroleoffreeradicalsinthepathogenesisofacutecerebralinfarction.MethodsPressCCSscoreof100patientswithacuteischemicstrokepatientsgroupdividedintolight,mediumgroupandseveregroup,andacontrolgroup100,respectively,bydoubleantibodysandwichELISAmethod,axanthineoxidasemethodandthecolorimetricdeterminationofbraindynamicsinfarctiongroupandcontrolgrouponday1,10daysaftertheonsetoforintotheperipheralbloodplasmaFgandSOD,MDAlevel,analyzetheirrelationships..ResultsFgplasmalevelsofcerebralinfarctionateachtimepointweresignificantlyhigherthanthecontrolgroup(P<0.01);thefirstdayoftheonsetofcerebralinfarctiongroup,SODlevelsweresignificantlylowerthanthecontrolgroup,MDAlevelwassignificantlyhigher(P<0.01)in10days,therewasnosignificantdifferencebetweenthetwogroups;Fgplasmalevelsinpatientswithacutecerebralinfarctionatonset,10daysandincreasedwiththeseverityofthethreegroupsweresignificantlydifferent(P<0.01),andSODandMDAlevelschange(P<0.01)onlyinthefirstonsetandseverityofgenius.ConclusionFg,MDAandSODtoparticipateintheprocessofcerebralvascularpathologyofacuteinjury,Fgcanbeusedtoassesspatientswithacutecerebralinfarctionseverityandprognosisofobjectiveindicators.【Keywords】Acutecerebralinfarction;fibrinogenfunctionAnticoagulant;Superoxide;Malondialdehyde纤维蛋白原与动脉血栓形成的关系己甚明确，它是动脉血栓事件后遗症的危险因素［1】。在急性脑梗死患者中，监测患者的血浆纤维蛋白原(Fg)含量及功能水平，冇助于对患者进行危险分层及制定治疗方案。而血清超氧化物歧化酶(SOD)和丙二醛(MDA)是反映氧自由基水平的主要观察指标，苏含量水平与脑梗死患者脑损伤的程度密切相关［2,3］。B前关于急性脑梗死患者血浆Fg与自由基之间关系的研究尚不多见，本研究通对急性脑梗死患者血浆Fg和SOD、MDA水平的动态观察，探讨它们在缺血性脑血管病中的作用及相互关系。1.资料与方法1.1一般资料收集我院神经内科自2012年1月至2015年1月收治的急性脑梗死住院患者100例为脑梗死组...