痔洗药促进大鼠创面愈合与改善创面微循环的实验研究黑龙江中医药大学黑龙江哈尔滨150040【摘要】目的：探讨痔洗药对大鼠创面愈合和微循环的影响。方法：大鼠造模后随机分为3组：痔洗药组，高猛酸钾组，混合对照组每组25只，痣洗药组动物右侧创面给痣洗药治疗，左侧创面给等量牛理盐水作为对照；高猛酸钾组动物右侧创面给高猛酸钾进行治疗，左侧创面给等量牛理盐水作为对照，混合组右侧创面给痣洗药治疗，左侧创面给高猛酸钾治疗，均每日给药两次，间隔10小时，于第3,7,14天测定创面新生肉芽组织成纤维细胞数量和新生毛细血管数量；于第3,7,11,21天测定肉芽组织蛋白质含量。经统计学分析，创面新牛肉芽组织成纤维细胞数量、新牛毛细血管数量和蛋白质含量痔洗药组优于其他两组(P<0.05)o结论：痔洗药能够显著促进大鼠创面愈合，改善创面微循环。【关键词】痔洗药；熏洗；创面；愈合；实验研究HemorrhoidmedicinetopromotewoundhealinginratsandimprovethemicrocirculationofexperimentalstudyofthewoundCHENGLi-ming,YANGWeiHeilongjiangUniversityofChineseMedicine,HAerbin150040,China；TheFirstAiliatedHospitalofHeilongjiangUniversityofChineseMedicine,Heilongjiang150040,ChinaAbstract:Objective：Itistodiscussthewashhemorrhoidsmedicineonwoundhealinginratsandtheeffectsofmicrocirculation.Methods：80SDratswererandomlydividedintohemorrhoidsmedicinegroup,thepotassiumpermanganategroupandmixedgroup,with25onesineachgroup.Besidethespineofrats1cm,eachdesigndiameterof1.8cmdeepanddeepfasciaandpartofthecircularmusclelayerwound,Washwashmedicinegroupofanimalsontherightsideofthewoundtoneimedicinetreatment(molewashmedicinegroupsamples),ontheleftsideofthewoundtotheamountofnormalsalineascontrolgroup(normalsailnesamples);Highfierceanimalsontherightsideofthewoundtohighacidpotassiumgroupfierceacidpotassiumtreatment(potassiumpermanganatesamples),ontheleftsideofthewoundtotheamountofnormalsalineascontrolsample(normalsalinegroup,mixedgroupontherightsideofthewoundcleaningnevusmedicinetreatment(molewashmedicinegroupsamples),ontheleftsideofthewoundtohighfierceacidpotassiumtreatment(potassiumpermanganategroupsamples),Bothgivemedicinetwotimesaday,eachtimetwice,inthedeterminationof3,7,14dayswoundgranulationtissuefibroblastsnewnumber(FGF)andnewbornbloodcapillarynumber(MVD);3,7,11,21daysinthedeterminationofgranulationtissueprotein(RP).Results:thewoundgranulationtissuefibroblastsnewnumber,newbornbloodcapillarynumber;andproteincontentofwashhemorrhoidsmedicinegroupissuperiortotheothertwogroups.7dayspostoperativelyinwoundgranulationtissueofratsnumberoffibroblastsandnewbornbloodcapillarynumber,washhemorrhoidsmedicinegroupisbetterthanthatofpotassiumpermanganateandnormalsalinegroup,differeneehasstatisticalsignificance(p<0.05),andpotassiumpermanganategrouphadnostatisticalsigrdficance.Postoperativeintermsofthetotalproteincontentinwoundtissueinrat,washhemorrhoidsmedicinegroupisbetterthanthatofpotassiumpermanganateandnormalsalinegroup,differeneehasstatisticalsignificanee(p<0.05),andpotassiumpermanganategrouphadnostatisticalsignificanee.Conclusion:washhemorrhoidsmedicinecanpromotewoundhealinginrats,improvethemicrocirculationofthewound.Keywords:Washhemorrhoidsmedicine;Fumigation;Thewound;He-aling【中图分类号］R269;R285.5【文献标识码】A【文章编号12096-0867(2016)15-219-02肛门病术后促进创面愈合和提高愈合质量一直是肛肠科面临的重大问题。除术中操作、减小创伤、和术后抗生素应用防止感染外，手术创面的用药也是加快愈合减小瘢痕增生的重要措施。痔洗药（主要由蒲公英、紫花地丁、黄柏、犬黄、艾叶、乌梅、元胡、五倍子、芒...