Careofhigh-dosemethotrexateforadultswithacutelymphoblasticleukemiaLargedosesofmethotrexate(HD-MTX),isthepreventionandtreatmentofadultacutelymphoblasticleukemia,andextramedullaryleukemiaandsystemicconsolidationandeffectivemeasurestostrengthenthetreatment.Tetrahydrofolate(CF4calciumrescue,buttheHD-MTXisametabolicanti-tumordrugtoxicity,thecourseoftreatmentisoftenaccompaniedbyvaryingdegreesoftoxici...
